4-[5-amino-3-(4-methylphenyl)-1H-pyrazol-1-yl]benzenesulfonamide

Base Information

• Chemical Name: 4-[5-amino-3-(4-methylphenyl)-1H-pyrazol-1-yl]benzenesulfonamide
• CAS No.: 1427266-41-8
• Molecular Formula: C₁₆H₁₆N₄O₂S
• Molecular Weight: 328.395
• Mol file: 1427266-41-8.mol

Synonyms:4-[5-amino-3-(4-methylphenyl)-1H-pyrazol-1-yl]benzenesulfonamide

Chemical Property of 4-[5-amino-3-(4-methylphenyl)-1H-pyrazol-1-yl]benzenesulfonamide

Chemical Property:

Purity/Quality:

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Technology Process of 4-[5-amino-3-(4-methylphenyl)-1H-pyrazol-1-yl]benzenesulfonamide

There total 1 articles about 4-[5-amino-3-(4-methylphenyl)-1H-pyrazol-1-yl]benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

4-hydrazinobenzenesulfonamide hydrochloride + p-tolueneacetonitrile (7391-28-8) → 4-[5-amino-3-(4-methylphenyl)-1H-pyrazol-1-yl]benzenesulfonamide (1427266-41-8)

Guidance literature:

With acetic acid; In ethanol; Reflux;

DOI:10.1007/s00044-013-0544-1

Reference yield: 94.0%

4-[5-amino-3-(4-methylphenyl)-1H-pyrazol-1-yl]benzenesulfonamide (1427266-41-8) + N,N-dimethyl-formamide dimethyl acetal (4637-24-5) → 4-[5-amino-3-(4-methylphenyl)-1H-pyrazol-1-yl]-N-[(dimethylamino)methylidene]benzenesulfonamide (1448798-90-0)

Guidance literature:

In neat (no solvent); at 20 ℃; for 0.25h; under 760.051 Torr; chemoselective reaction; Green chemistry;

DOI:10.1039/c3gc40797g

Reference yield: 80.0%

1,1,1,5,5,5-hexafluoroacetylacetone (1522-22-1) + 4-[5-amino-3-(4-methylphenyl)-1H-pyrazol-1-yl]benzenesulfonamide (1427266-41-8) → N-[1-[4-(aminosulfonyl)phenyl]-3-(4-methylphenyl)-1H-pyrazol-5-yl]acetamide + 4-[3-(4-methylphenyl)-4,6-bis(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl]benzenesulfonamide

Guidance literature:

With acetic acid; Reflux;

DOI:10.1007/s00044-013-0544-1

upstream raw materials:

p-tolueneacetonitrile

Downstream raw materials:

4-[5-amino-3-(4-methylphenyl)-1H-pyrazol-1-yl]-N-[(dimethylamino)methylidene]benzenesulfonamide