2-{1-[(Z)-Hydroxyimino]-ethyl}-3-methyl-5-oxo-7-phenyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid amide

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Chemical Name:2-{1-[(Z)-Hydroxyimino]-ethyl}-3-methyl-5-oxo-7-phenyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid amide
CAS No.:118521-09-8
Molecular Formula:C₁₆H₁₄N₄O₃S
Molecular Weight:342.378
Hs Code.:

Synonyms:2-{1-[(Z)-Hydroxyimino]-ethyl}-3-methyl-5-oxo-7-phenyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid amide

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Chemical Property of 2-{1-[(Z)-Hydroxyimino]-ethyl}-3-methyl-5-oxo-7-phenyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid amide

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Technology Process of 2-{1-[(Z)-Hydroxyimino]-ethyl}-3-methyl-5-oxo-7-phenyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid amide

There total 4 articles about 2-{1-[(Z)-Hydroxyimino]-ethyl}-3-methyl-5-oxo-7-phenyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 118521-08-7
2-acetyl-6-carboxamido-5H-3-methyl-7-phenylthiazolo<3,2-a>pyrimidin-5-one

: 118521-09-8
2-{1-[(Z)-Hydroxyimino]-ethyl}-3-methyl-5-oxo-7-phenyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid amide

Guidance literature:: With hydroxylamine hydrochloride; sodium acetate; In acetic acid; for 0.5h; Heating;
DOI:10.1002/jhet.5570240621

Reference yield:

: 118521-01-0
5-cyano-2-(2',4'-dioxopentan-3'-ylthio)-6-phenyl-3,4-dihydropyrimidin-4-one

: 118521-09-8
2-{1-[(Z)-Hydroxyimino]-ethyl}-3-methyl-5-oxo-7-phenyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid amide

Guidance literature:: Multi-step reaction with 2 steps

1: 60 percent / polyphosphoric acid / 2 h / 1.) 100 deg C, 1 h; 2.) 120 deg C, 1 h.

2: 75 percent / NH₂OH*HCl, CH₃COONa / acetic acid / 0.5 h / Heating

With PPA; hydroxylamine hydrochloride; sodium acetate; In acetic acid;
DOI:10.1002/jhet.5570240621

Reference yield:

: 1694-29-7
3-chloropentane-2,4-dione

: 118521-09-8
2-{1-[(Z)-Hydroxyimino]-ethyl}-3-methyl-5-oxo-7-phenyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid amide

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) aq. KOH / 1.) EtOH, 70 deg C - 80 deg C, 10 min; 2.) room temp., 18 h.

2: 60 percent / polyphosphoric acid / 2 h / 1.) 100 deg C, 1 h; 2.) 120 deg C, 1 h.

3: 75 percent / NH₂OH*HCl, CH₃COONa / acetic acid / 0.5 h / Heating

With potassium hydroxide; PPA; hydroxylamine hydrochloride; sodium acetate; In acetic acid;
DOI:10.1002/jhet.5570240621