1-(4-fluorophenyl)-2-((1S,2R)-1-hydroxy-1,2-dihydronaphthalen-2-yl)ethanone

Base Information

Chemical Name:1-(4-fluorophenyl)-2-((1S,2R)-1-hydroxy-1,2-dihydronaphthalen-2-yl)ethanone
CAS No.:1629211-55-7
Molecular Formula:C₁₈H₁₅FO₂
Molecular Weight:282.314
Hs Code.:

Synonyms:1-(4-fluorophenyl)-2-((1S,2R)-1-hydroxy-1,2-dihydronaphthalen-2-yl)ethanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(4-fluorophenyl)-2-((1S,2R)-1-hydroxy-1,2-dihydronaphthalen-2-yl)ethanone

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Technology Process of 1-(4-fluorophenyl)-2-((1S,2R)-1-hydroxy-1,2-dihydronaphthalen-2-yl)ethanone

There total 2 articles about 1-(4-fluorophenyl)-2-((1S,2R)-1-hydroxy-1,2-dihydronaphthalen-2-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1642118-05-5
2-((1S,2R)-1-((tert-butyldimethylsilyl)oxy)-1,2-dihydronaphthalen-2-yl)-1-(4-fluorophenyl)ethanone

: 1629211-55-7
1-(4-fluorophenyl)-2-((1S,2R)-1-hydroxy-1,2-dihydronaphthalen-2-yl)ethanone

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; Inert atmosphere;
DOI:10.1002/anie.201400218

Reference yield:

: 573-57-9
1,4-dihydronaphthalene-1,4-epoxide

: 1629211-55-7
1-(4-fluorophenyl)-2-((1S,2R)-1-hydroxy-1,2-dihydronaphthalen-2-yl)ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: bis(1,5-cyclooctadiene)rhodium(I) trifluoromethanesulfonate; (R)-1-[(S)-2-(di-tert-butylphosphino)ferrocenyl]ethyl-di-2-methylphenylphosphine; zinc trifluoromethanesulfonate / tetrahydrofuran / 3 h / 50 °C / Inert atmosphere; Sealed tube

2: tetrabutyl ammonium fluoride / tetrahydrofuran / Inert atmosphere

With bis(1,5-cyclooctadiene)rhodium(I) trifluoromethanesulfonate; (R)-1-[(S)-2-(di-tert-butylphosphino)ferrocenyl]ethyl-di-2-methylphenylphosphine; tetrabutyl ammonium fluoride; zinc trifluoromethanesulfonate; In tetrahydrofuran;
DOI:10.1002/anie.201400218