(R)-3,10-dibromo-6-phenyl-6H-benzo[5,6][1,3]oxazino[3,4-a]-indole

Base Information

• Chemical Name: (R)-3,10-dibromo-6-phenyl-6H-benzo[5,6][1,3]oxazino[3,4-a]-indole
• CAS No.: 1392102-37-2
• Molecular Formula: C₂₁H₁₃Br₂NO
• Molecular Weight: 455.148
• Mol file: 1392102-37-2.mol

Synonyms:(R)-3,10-dibromo-6-phenyl-6H-benzo[5,6][1,3]oxazino[3,4-a]-indole

Chemical Property of (R)-3,10-dibromo-6-phenyl-6H-benzo[5,6][1,3]oxazino[3,4-a]-indole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-3,10-dibromo-6-phenyl-6H-benzo[5,6][1,3]oxazino[3,4-a]-indole

There total 11 articles about (R)-3,10-dibromo-6-phenyl-6H-benzo[5,6][1,3]oxazino[3,4-a]-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4'-bromo-2'-hydroxyacetophenone (30186-18-6) → (S)-3,10-dibromo-6-phenyl-6H-benzo[5,6][1,3]oxazino[3,4-a]-indole (1392102-38-3) + (R)-3,10-dibromo-6-phenyl-6H-benzo[5,6][1,3]oxazino[3,4-a]-indole (1392102-37-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: acetic acid / ethanol / Reflux

1.2: PPA / 110 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 100 °C

With potassium carbonate; acetic acid; In ethanol; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2016.06.063

Reference yield:

(6S,12aR)-3,10-dibromo-6-phenyl-12,12a-dihydro-6H-benzo-[5,6][1,3]oxazino[3,4-a]indole (1585969-16-9) → (S)-3,10-dibromo-6-phenyl-6H-benzo[5,6][1,3]oxazino[3,4-a]-indole (1392102-38-3) + (R)-3,10-dibromo-6-phenyl-6H-benzo[5,6][1,3]oxazino[3,4-a]-indole (1392102-37-2)

Guidance literature:

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; at 20 ℃; Reagent/catalyst; Solvent; Temperature; Inert atmosphere;

DOI:10.1021/jo501581e

Reference yield:

3,10-dibromo-6-phenyl-6H-benzo[5,6][1,3]oxazino[3,4-a]indole (1369594-56-8) → (S)-3,10-dibromo-6-phenyl-6H-benzo[5,6][1,3]oxazino[3,4-a]-indole (1392102-38-3) + (R)-3,10-dibromo-6-phenyl-6H-benzo[5,6][1,3]oxazino[3,4-a]-indole (1392102-37-2)

Guidance literature:

With Chiral AD; In methanol; carbon dioxide; acetonitrile; Purification / work up; Resolution of racemate;

upstream raw materials:

4'-bromo-2'-hydroxyacetophenone

C₁₄H₁₂Br₂N₂O

5-bromo-2-(5-bromo-1H-indol-2-yl)phenol

3,10-dibromo-6-phenyl-6H-benzo[5,6][1,3]oxazino[3,4-a]indole