(E)-methyl 3,5-difluoro-2-(3-(4-fluorophenyl)-2-(1-methyl-1H-1,2,4-triazol-5-yl)acryloyl)benzoate

Base Information

Chemical Name:(E)-methyl 3,5-difluoro-2-(3-(4-fluorophenyl)-2-(1-methyl-1H-1,2,4-triazol-5-yl)acryloyl)benzoate
CAS No.:1425498-44-7
Molecular Formula:C₂₀H₁₄F₃N₃O₃
Molecular Weight:401.345
Hs Code.:

Synonyms:(E)-methyl 3,5-difluoro-2-(3-(4-fluorophenyl)-2-(1-methyl-1H-1,2,4-triazol-5-yl)acryloyl)benzoate

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Chemical Property of (E)-methyl 3,5-difluoro-2-(3-(4-fluorophenyl)-2-(1-methyl-1H-1,2,4-triazol-5-yl)acryloyl)benzoate

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Technology Process of (E)-methyl 3,5-difluoro-2-(3-(4-fluorophenyl)-2-(1-methyl-1H-1,2,4-triazol-5-yl)acryloyl)benzoate

There total 6 articles about (E)-methyl 3,5-difluoro-2-(3-(4-fluorophenyl)-2-(1-methyl-1H-1,2,4-triazol-5-yl)acryloyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 1425498-32-3
methyl 3,5-difluoro-2-(2-(1-methyl-1H-1,2,4-triazol-5-yl)acetyl)benzoate

: 459-57-4
4-fluorobenzaldehyde

: 1425498-44-7
(E)-methyl 3,5-difluoro-2-(3-(4-fluorophenyl)-2-(1-methyl-1H-1,2,4-triazol-5-yl)acryloyl)benzoate

Guidance literature:: With L-proline; In dimethyl sulfoxide; at 45 ℃; for 48h;

Reference yield:

: 1207453-91-5
4-amino-6-fluoroisobenzofuran-1(3H)-one

: 1425498-44-7
(E)-methyl 3,5-difluoro-2-(3-(4-fluorophenyl)-2-(1-methyl-1H-1,2,4-triazol-5-yl)acryloyl)benzoate

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride; hexafluorophosphoric acid; sodium nitrite / water / 4 h / -10 - 0 °C

1.2: 120 - 150 °C

2.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane; water / 2 h / Reflux

3.1: toluene / 3 h / 100 °C / Inert atmosphere

4.1: triethylamine / dichloromethane / 3.5 h / 0 - 10 °C

5.1: 20 °C

6.1: L-proline / dimethyl sulfoxide / 48 h / 45 °C

With hydrogenchloride; N-Bromosuccinimide; hexafluorophosphoric acid; triethylamine; L-proline; sodium nitrite; dibenzoyl peroxide; In tetrachloromethane; dichloromethane; water; dimethyl sulfoxide; toluene;

Reference yield:

: 1425498-30-1
(5,7-difluoro-3-oxo-1,3-dihydroisobenzofuran-1-yl)triphenylphosphonium bromide

: 1425498-44-7
(E)-methyl 3,5-difluoro-2-(3-(4-fluorophenyl)-2-(1-methyl-1H-1,2,4-triazol-5-yl)acryloyl)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 3.5 h / 0 - 10 °C

2: 20 °C

3: L-proline / dimethyl sulfoxide / 48 h / 45 °C

With triethylamine; L-proline; In dichloromethane; dimethyl sulfoxide;