Ammonium (Z)-2-(furan-2-yl)-2-(methoxyimino)acetate

Base Information

• Chemical Name: Ammonium (Z)-2-(furan-2-yl)-2-(methoxyimino)acetate
• CAS No.: 97148-39-5
• Molecular Formula: C7H10N2O4
• Molecular Weight: 186.167
• Hs Code.: 29321900
• European Community (EC) Number: 405-990-1,619-259-1
• DSSTox Substance ID: DTXSID301334946
• Mol file: 97148-39-5.mol

Synonyms:97148-39-5;azanium;(2Z)-2-(furan-2-yl)-2-methoxyiminoacetate;Ammonium (Z)-2-(furan-2-yl)-2-(methoxyimino)acetate;Ammonium 2-Furyl(methoxyimino)acetate;97148-89-5;Cefuroxime Sodium EP Impurity I Ammonium Salt ((Z)-2-Methoxyimino-2-furanacetic Acid Ammonium Salt);SYN-METHOXYIMINOFURANGLYCOLIC ACID, AMMONIUM SALT;AMMONIUM (2Z)-2-(FURAN-2-YL)-2-(METHOXYIMINO)ACETATE;SCHEMBL5211578;DTXSID301334946;MFCD03791040;AKOS015900509;AC-2031;AC-5581;ammonium 2-(2-furyl)-2-methoxyimino-acetate;A845687;J-519586;Ammonium(Z)-2-(furan-2-yl)-2-(methoxyimino)acetate;SYN-2-METHOXYIMINO-2-(2-FURYL)-ACETIC ACID AMMONIUM SALT;(alphaZ)-alpha-(Methoxyimino)-2-furanacetic acid ammonium salt (1:1)

Chemical Property of Ammonium (Z)-2-(furan-2-yl)-2-(methoxyimino)acetate

Chemical Property:

• Appearance/Colour: light yellow-beige to beige crystalline powder
• Vapor Pressure: 0.00138mmHg at 25°C
• Melting Point: 182oC
• Refractive Index: 1.5010 (estimate)
• Boiling Point: 284.7 °C at 760 mmHg
• Flash Point: 126 °C
• PSA: 74.86000
• Density: 1.4172 (rough estimate)
• LogP: -0.24380
• Storage Temp.: -20°C
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 2
• Exact Mass: 186.06405680
• Heavy Atom Count: 13
• Complexity: 196

Purity/Quality:

99% ^*data from raw suppliers

(Z)-2-Methoxyimino-2-furanaceticAcidAmmoniumSalt ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi, F
• Hazard Codes: Xi,F
• Statements: 36/37/38-11
• Safety Statements: 24/25-43-22-2-43A

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CON=C(C1=CC=CO1)C(=O)[O-].[NH4+]
• Isomeric SMILES: CO/N=C(/C1=CC=CO1)\C(=O)[O-].[NH4+]

Technology Process of Ammonium (Z)-2-(furan-2-yl)-2-(methoxyimino)acetate

There total 1 articles about Ammonium (Z)-2-(furan-2-yl)-2-(methoxyimino)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(E)-2-methoxyimino-2-(furan-2-yl)acetic acid ammonium → (Z)-2-methoxyimino-2-(furyl-2-yl)acetic acid ammonium salt (97148-39-5)

Guidance literature:

With hydrogenated catalyst Fe₃P; In dichloromethane; at 0 ℃; for 1h; Temperature; Solvent; Concentration; Reagent/catalyst; Large scale; Green chemistry;

Reference yield: 89.1%

(Z)-2-methoxyimino-2-(furyl-2-yl)acetic acid ammonium salt (97148-39-5) + (6R,7R)-7-amino-3-hydroxymethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid (15690-38-7) → (6R,7R)-7-[2-(2-furyl)-2-(methoxyimino)acetamido]-3-hydroxymethyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (56271-94-4)

Guidance literature:

(Z)-2-methoxyimino-2-(furyl-2-yl)acetic acid ammonium salt; With N,N-dimethyl acetamide; phosphorus pentachloride; In dichloromethane; at -30 - -10 ℃; for 1.33333h;

(6R,7R)-7-amino-3-hydroxymethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid; With sodium hydroxide; In dichloromethane; water; for 2h; pH=6.5 - 7;

Reference yield:

(Z)-2-methoxyimino-2-(furyl-2-yl)acetic acid ammonium salt (97148-39-5) → Cefuroxime (55268-75-2)

Guidance literature:

Multi-step reaction with 4 steps

1.1: triethylamine / chloroform / 0.17 h / 5 °C

1.2: 1 h

2.1: triethylamine; chloro-trimethyl-silane / chloroform / 0.5 h / 5 °C

2.2: 4 h / 5 °C

3.1: water; sodium hydroxide / methanol / 1 h / -15 - 5 °C

4.1: acetone / 1 h / 5 °C

4.2: 4 h / 45 °C

With chloro-trimethyl-silane; water; triethylamine; sodium hydroxide; In methanol; chloroform; acetone;

Downstream raw materials:

(6R,7R)-7-[2-(2-furyl)-2-(methoxyimino)acetamido]-3-hydroxymethyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Cefuroxime

7-[(Z)-2-Furyl-2-methoxyiminoacetamido]-3-acetoxymethyl-3-cephalosporanic acid

cefuroxime

Refernces