2-(4-Carboxy-benzyl)-2-{(Z)-4-[(6-hydroxy-hexyl)-(2-nitro-benzenesulfonyl)-amino]-but-2-enyl}-malonic acid dimethyl ester

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Chemical Name:2-(4-Carboxy-benzyl)-2-{(Z)-4-[(6-hydroxy-hexyl)-(2-nitro-benzenesulfonyl)-amino]-but-2-enyl}-malonic acid dimethyl ester
CAS No.:292819-44-4
Molecular Formula:C₂₉H₃₆N₂O₁₁S
Molecular Weight:620.678
Hs Code.:

Synonyms:2-(4-Carboxy-benzyl)-2-{(Z)-4-[(6-hydroxy-hexyl)-(2-nitro-benzenesulfonyl)-amino]-but-2-enyl}-malonic acid dimethyl ester

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Chemical Property of 2-(4-Carboxy-benzyl)-2-{(Z)-4-[(6-hydroxy-hexyl)-(2-nitro-benzenesulfonyl)-amino]-but-2-enyl}-malonic acid dimethyl ester

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Technology Process of 2-(4-Carboxy-benzyl)-2-{(Z)-4-[(6-hydroxy-hexyl)-(2-nitro-benzenesulfonyl)-amino]-but-2-enyl}-malonic acid dimethyl ester

There total 8 articles about 2-(4-Carboxy-benzyl)-2-{(Z)-4-[(6-hydroxy-hexyl)-(2-nitro-benzenesulfonyl)-amino]-but-2-enyl}-malonic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 2-[4-(4-Benzyloxy-benzyloxycarbonyl)-benzyl]-2-((Z)-4-{(2-nitro-benzenesulfonyl)-[6-(tetrahydro-pyran-2-yloxy)-hexyl]-amino}-but-2-enyl)-malonic acid dimethyl ester

: 292819-44-4
2-(4-Carboxy-benzyl)-2-{(Z)-4-[(6-hydroxy-hexyl)-(2-nitro-benzenesulfonyl)-amino]-but-2-enyl}-malonic acid dimethyl ester

Guidance literature:: With phosphate buffer; trifluoroacetic acid; In methanol; dichloromethane; at 20 ℃; for 19h; pH=7;
DOI:10.1016/S0040-4039(00)00711-5

Reference yield:

: 4048-33-3
6-amino-1-hexanol

: 292819-44-4
2-(4-Carboxy-benzyl)-2-{(Z)-4-[(6-hydroxy-hexyl)-(2-nitro-benzenesulfonyl)-amino]-but-2-enyl}-malonic acid dimethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 2N NaOH / ethyl acetate; H₂O

1.2: 54 percent / PTSA

2.1: 95 percent / DEAD; Ph₃P / tetrahydrofuran / 5 h / 20 °C

3.1: 90 percent / TFA; phosphate buffer / CH₂Cl₂; methanol / 19 h / 20 °C / pH 7

With sodium hydroxide; phosphate buffer; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; 1.1: nosylation / 1.2: Etherification / 2.1: Mitsunobu reaction / 3.1: Hydrolysis;
DOI:10.1016/S0040-4039(00)00711-5

Reference yield:

: 876-08-4
p-(chloromethyl)benzoyl chloride

: 292819-44-4
2-(4-Carboxy-benzyl)-2-{(Z)-4-[(6-hydroxy-hexyl)-(2-nitro-benzenesulfonyl)-amino]-but-2-enyl}-malonic acid dimethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 93 percent / DMAP / CH₂Cl₂; dimethylformamide / 6 h / 20 °C

2: 86 percent / KH; KI / dimethylformamide; tetrahydrofuran / 5 h / 20 °C

3: 79 percent / PTSA / CH₂Cl₂; methanol / 18 h / 20 °C

4: 95 percent / DEAD; Ph₃P / tetrahydrofuran / 5 h / 20 °C

5: 90 percent / TFA; phosphate buffer / CH₂Cl₂; methanol / 19 h / 20 °C / pH 7

With dmap; phosphate buffer; potassium hydride; toluene-4-sulfonic acid; triphenylphosphine; trifluoroacetic acid; potassium iodide; diethylazodicarboxylate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; 1: Esterification / 2: Substitution / 3: Hydrolysis / 4: Mitsunobu reaction / 5: Hydrolysis;
DOI:10.1016/S0040-4039(00)00711-5