methyl 2-{3-[N-(2-aminoacetyl)-N-(N-methyl-N-phenylcarbamoylmethyl)amino]phenoxy}acetate

Base Information

Chemical Name:methyl 2-{3-[N-(2-aminoacetyl)-N-(N-methyl-N-phenylcarbamoylmethyl)amino]phenoxy}acetate
CAS No.:205694-33-3
Molecular Formula:C₂₀H₂₃N₃O₅
Molecular Weight:385.42
Hs Code.:

Synonyms:methyl 2-{3-[N-(2-aminoacetyl)-N-(N-methyl-N-phenylcarbamoylmethyl)amino]phenoxy}acetate

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Chemical Property of methyl 2-{3-[N-(2-aminoacetyl)-N-(N-methyl-N-phenylcarbamoylmethyl)amino]phenoxy}acetate

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Technology Process of methyl 2-{3-[N-(2-aminoacetyl)-N-(N-methyl-N-phenylcarbamoylmethyl)amino]phenoxy}acetate

There total 5 articles about methyl 2-{3-[N-(2-aminoacetyl)-N-(N-methyl-N-phenylcarbamoylmethyl)amino]phenoxy}acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 205694-26-4
methyl 2-(3-{N-[2-(N-tert-butoxycarbonylamino)acetyl]-N-(N-methyl-N-phenylcarbamoylmethyl)amino}phenoxy)acetate

: 205694-33-3
methyl 2-{3-[N-(2-aminoacetyl)-N-(N-methyl-N-phenylcarbamoylmethyl)amino]phenoxy}acetate

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 0.5h;
DOI:10.1248/cpb.46.434

Reference yield:

: 554-84-7
meta-nitrophenol

: 205694-33-3
methyl 2-{3-[N-(2-aminoacetyl)-N-(N-methyl-N-phenylcarbamoylmethyl)amino]phenoxy}acetate

Guidance literature:: Multi-step reaction with 5 steps

1: 82 percent / K₂CO₃ / dimethylformamide / 3 h / 70 °C

2: 94 percent / H₂ / 5percent Pd/C / methanol; ethyl acetate / 0.75 h / 760 Torr

3: 75 percent / EDC*HCl, DMAP / CH₂Cl₂ / Ambient temperature

4: 1.) NaH / 1.) THF, 60 deg C, 15 min, 2.) THF, RT, 1.5 h

5: 100 percent / TFA / CH₂Cl₂ / 0.5 h

With dmap; hydrogen; sodium hydride; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; palladium on activated charcoal; In methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1248/cpb.46.434

Reference yield:

: 81720-19-6
1-methoxycarbonylmethyloxy-3-nitrobenzene

: 205694-33-3
methyl 2-{3-[N-(2-aminoacetyl)-N-(N-methyl-N-phenylcarbamoylmethyl)amino]phenoxy}acetate

Guidance literature:: Multi-step reaction with 4 steps

1: 94 percent / H₂ / 5percent Pd/C / methanol; ethyl acetate / 0.75 h / 760 Torr

2: 75 percent / EDC*HCl, DMAP / CH₂Cl₂ / Ambient temperature

3: 1.) NaH / 1.) THF, 60 deg C, 15 min, 2.) THF, RT, 1.5 h

4: 100 percent / TFA / CH₂Cl₂ / 0.5 h

With dmap; hydrogen; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; palladium on activated charcoal; In methanol; dichloromethane; ethyl acetate;
DOI:10.1248/cpb.46.434