2-[[N-[3β,23-dihydroxylup-20(29)-en-28-oyl]-3-aminopropyl]carbamoyl]benzoic acid

Base Information

• Chemical Name: 2-[[N-[3β,23-dihydroxylup-20(29)-en-28-oyl]-3-aminopropyl]carbamoyl]benzoic acid
• CAS No.: 1544635-04-2
• Molecular Formula: C₄₅H₆₄N₂O₈
• Molecular Weight: 761.012
• Mol file: 1544635-04-2.mol

Synonyms:2-[[N-[3β,23-dihydroxylup-20(29)-en-28-oyl]-3-aminopropyl]carbamoyl]benzoic acid

Chemical Property of 2-[[N-[3β,23-dihydroxylup-20(29)-en-28-oyl]-3-aminopropyl]carbamoyl]benzoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[[N-[3β,23-dihydroxylup-20(29)-en-28-oyl]-3-aminopropyl]carbamoyl]benzoic acid

There total 4 articles about 2-[[N-[3β,23-dihydroxylup-20(29)-en-28-oyl]-3-aminopropyl]carbamoyl]benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

phthalic anhydride (85-44-9) + N-[3β,23-diacetoxylup-20(29)-en-28-oyl]-1,3-diaminopropane (1204202-48-1) → 2-[[N-[3β,23-dihydroxylup-20(29)-en-28-oyl]-3-aminopropyl]carbamoyl]benzoic acid (1544635-04-2)

Guidance literature:

phthalic anhydride; N-[3β,23-diacetoxylup-20(29)-en-28-oyl]-1,3-diaminopropane; With dmap; In dichloromethane; for 8h;

With hydrogenchloride; In water; acetone; pH=2;

DOI:10.2174/1573406411309070005

Reference yield:

23-hydroxybetulinic acid (85999-40-2) → 2-[[N-[3β,23-dihydroxylup-20(29)-en-28-oyl]-3-aminopropyl]carbamoyl]benzoic acid (1544635-04-2)

Guidance literature:

Multi-step reaction with 4 steps

1.1: pyridine / 20 °C

2.1: dichloromethane / 4 h / 20 °C

3.1: dichloromethane / 8 h / 20 °C

4.1: dmap / dichloromethane / 8 h

4.2: pH 2

With pyridine; dmap; In dichloromethane;

DOI:10.2174/1573406411309070005

Reference yield:

acetic acid 8-acetoxymethyl-3a-chlorocarbonyl-1-isopropenyl-5a,5b,8,11a-tetramethyl-eicosahydro-cyclopenta[a]chrysen-9-yl ester (916139-48-5) → 2-[[N-[3β,23-dihydroxylup-20(29)-en-28-oyl]-3-aminopropyl]carbamoyl]benzoic acid (1544635-04-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: dichloromethane / 8 h / 20 °C

2.1: dmap / dichloromethane / 8 h

2.2: pH 2

With dmap; In dichloromethane;

DOI:10.2174/1573406411309070005

upstream raw materials:

acetic acid 8-acetoxymethyl-3a-chlorocarbonyl-1-isopropenyl-5a,5b,8,11a-tetramethyl-eicosahydro-cyclopenta[a]chrysen-9-yl ester

23-hydroxybetulinic acid

phthalic anhydride

N-[3β,23-diacetoxylup-20(29)-en-28-oyl]-1,3-diaminopropane