3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethyl-N-[5-(3-fluorophenyl)-1,3,4-thiadiazol-2-yl]cyclopropanecarboxamide

Base Information

Chemical Name:3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethyl-N-[5-(3-fluorophenyl)-1,3,4-thiadiazol-2-yl]cyclopropanecarboxamide
CAS No.:1293376-72-3
Molecular Formula:C₁₇H₁₄ClF₄N₃OS
Molecular Weight:419.83
Hs Code.:

Synonyms:3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethyl-N-[5-(3-fluorophenyl)-1,3,4-thiadiazol-2-yl]cyclopropanecarboxamide

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Chemical Property of 3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethyl-N-[5-(3-fluorophenyl)-1,3,4-thiadiazol-2-yl]cyclopropanecarboxamide

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Technology Process of 3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethyl-N-[5-(3-fluorophenyl)-1,3,4-thiadiazol-2-yl]cyclopropanecarboxamide

There total 2 articles about 3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethyl-N-[5-(3-fluorophenyl)-1,3,4-thiadiazol-2-yl]cyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.5%

: 74609-46-4
3-(2-chloro-3,3,3-trifluoroprop-1-en-yl)-2,2-dimethylcyclopropanecarboxylic acid

: 59565-52-5
5-(3-fluorophenyl)-1,3,4-thiadiazol-2-amine

: 1293376-72-3
3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethyl-N-[5-(3-fluorophenyl)-1,3,4-thiadiazol-2-yl]cyclopropanecarboxamide

Guidance literature:: With O-phenyl phosphorodichloridate; triethylamine; In dichloromethane; at 0 - 5 ℃; Inert atmosphere;
DOI:10.3184/030823410X12889042123874

Reference yield:

: 455-38-9
3-fluorobenzoic acid

: 1293376-72-3
3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethyl-N-[5-(3-fluorophenyl)-1,3,4-thiadiazol-2-yl]cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: trichlorophosphate / 0 °C / Reflux; Inert atmosphere

2: O-phenyl phosphorodichloridate; triethylamine / dichloromethane / 0 - 5 °C / Inert atmosphere

With O-phenyl phosphorodichloridate; triethylamine; trichlorophosphate; In dichloromethane;
DOI:10.3184/030823410X12889042123874