(1R,2'R)-1-phenyl-2-[N(1')-(tert-butoxycarbonyl)pyrrolidin-2'-yl]ethanol

Base Information

Chemical Name:(1R,2'R)-1-phenyl-2-[N(1')-(tert-butoxycarbonyl)pyrrolidin-2'-yl]ethanol
CAS No.:1202039-20-0
Molecular Formula:C₁₇H₂₅NO₃
Molecular Weight:291.39
Hs Code.:

Synonyms:(1R,2'R)-1-phenyl-2-[N(1')-(tert-butoxycarbonyl)pyrrolidin-2'-yl]ethanol

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Chemical Property of (1R,2'R)-1-phenyl-2-[N(1')-(tert-butoxycarbonyl)pyrrolidin-2'-yl]ethanol

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Technology Process of (1R,2'R)-1-phenyl-2-[N(1')-(tert-butoxycarbonyl)pyrrolidin-2'-yl]ethanol

There total 2 articles about (1R,2'R)-1-phenyl-2-[N(1')-(tert-butoxycarbonyl)pyrrolidin-2'-yl]ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1202039-18-6
(R)-1-phenyl-2-[N(1')-(tert-butoxycarbonyl)pyrrolidin-2'-yl]ethanone

: 1202039-20-0
(1R,2'R)-1-phenyl-2-[N(1')-(tert-butoxycarbonyl)pyrrolidin-2'-yl]ethanol

Guidance literature:: With lithium tri-t-butoxyaluminum hydride; In tetrahydrofuran; at 0 ℃; for 6h; optical yield given as %de; stereoselective reaction; Inert atmosphere;
DOI:10.1016/j.tet.2009.09.104

Reference yield: 71.0%

: 1202039-18-6
(R)-1-phenyl-2-[N(1')-(tert-butoxycarbonyl)pyrrolidin-2'-yl]ethanone

: 1202039-21-1
(1S,2'R)-1-phenyl-2-[N(1')-(tert-butoxycarbonyl)pyrrolidin-2'-yl]ethanol

: 1202039-20-0
(1R,2'R)-1-phenyl-2-[N(1')-(tert-butoxycarbonyl)pyrrolidin-2'-yl]ethanol

Guidance literature:: With borane-THF; (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole; In tetrahydrofuran; toluene; at 0 ℃; for 2h; optical yield given as %de; stereoselective reaction;
DOI:10.1016/j.tet.2009.09.104

Reference yield: 81.0%

: 1202039-20-0
(1R,2'R)-1-phenyl-2-[N(1')-(tert-butoxycarbonyl)pyrrolidin-2'-yl]ethanol

: 134877-23-9
(R)-1-Phenyl-2-<(R)-2-pyrrolidinyl>ethanol

Guidance literature:: (1R,2'R)-1-phenyl-2-[N(1')-(tert-butoxycarbonyl)pyrrolidin-2'-yl]ethanol; With hydrogenchloride; water; In methanol; at 50 ℃; for 3h;

With sodium hydroxide; In water; optical yield given as %de;
DOI:10.1016/j.tet.2009.09.104