3-(2-diethoxyphosphinylbenzyl)-1-(tetrahydrofuran-2-yl)pyrimidine-2,4-dione

Base Information

Chemical Name:3-(2-diethoxyphosphinylbenzyl)-1-(tetrahydrofuran-2-yl)pyrimidine-2,4-dione
CAS No.:887246-99-3
Molecular Formula:C₁₉H₂₅N₂O₆P
Molecular Weight:408.391
Hs Code.:

Synonyms:3-(2-diethoxyphosphinylbenzyl)-1-(tetrahydrofuran-2-yl)pyrimidine-2,4-dione

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Chemical Property of 3-(2-diethoxyphosphinylbenzyl)-1-(tetrahydrofuran-2-yl)pyrimidine-2,4-dione

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Technology Process of 3-(2-diethoxyphosphinylbenzyl)-1-(tetrahydrofuran-2-yl)pyrimidine-2,4-dione

There total 4 articles about 3-(2-diethoxyphosphinylbenzyl)-1-(tetrahydrofuran-2-yl)pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 75777-37-6
(2-bromomethyl-phenyl)-phosphonic acid diethyl ester

: 18002-26-1
1-(tetrahydro-furan-2-yl)-uracil

: 887246-99-3
3-(2-diethoxyphosphinylbenzyl)-1-(tetrahydrofuran-2-yl)pyrimidine-2,4-dione

Guidance literature:: 1-(tetrahydro-furan-2-yl)-uracil; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

(2-bromomethyl-phenyl)-phosphonic acid diethyl ester; In N,N-dimethyl-formamide; at 60 ℃; for 48h;
DOI:10.1021/jm051086f

Reference yield:

: 95-46-5
2-methylphenyl bromide

: 887246-99-3
3-(2-diethoxyphosphinylbenzyl)-1-(tetrahydrofuran-2-yl)pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: 79 percent / nickel(II) bromide / 2.5 h / Heating

2.1: benzoyl peroxide; NBS / CCl₄ / 26 h / Irradiation; heating

3.1: sodium hydride / dimethylformamide / 2 h / 20 °C

3.2: 2.17 g / dimethylformamide / 48 h / 60 °C

With N-Bromosuccinimide; sodium hydride; nickel dibromide; dibenzoyl peroxide; In tetrachloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm051086f

Reference yield:

: 15286-11-0
diethyl o-tolylphosphonate

: 887246-99-3
3-(2-diethoxyphosphinylbenzyl)-1-(tetrahydrofuran-2-yl)pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1.1: benzoyl peroxide; NBS / CCl₄ / 26 h / Irradiation; heating

2.1: sodium hydride / dimethylformamide / 2 h / 20 °C

2.2: 2.17 g / dimethylformamide / 48 h / 60 °C

With N-Bromosuccinimide; sodium hydride; dibenzoyl peroxide; In tetrachloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm051086f