N-{5-[5-(3,3-difluorocyclobutyl)-1,2,4-oxadiazol-3-yl]-2-methylphenyl}-6-[(2-fluoroethoxy)methyl]imidazo[1,2-a]pyridine-3-carboxamide

Base Information

Chemical Name:N-{5-[5-(3,3-difluorocyclobutyl)-1,2,4-oxadiazol-3-yl]-2-methylphenyl}-6-[(2-fluoroethoxy)methyl]imidazo[1,2-a]pyridine-3-carboxamide
CAS No.:1426448-74-9
Molecular Formula:C₂₄H₂₂F₃N₅O₃
Molecular Weight:485.466
Hs Code.:

Synonyms:N-{5-[5-(3,3-difluorocyclobutyl)-1,2,4-oxadiazol-3-yl]-2-methylphenyl}-6-[(2-fluoroethoxy)methyl]imidazo[1,2-a]pyridine-3-carboxamide

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Chemical Property of N-{5-[5-(3,3-difluorocyclobutyl)-1,2,4-oxadiazol-3-yl]-2-methylphenyl}-6-[(2-fluoroethoxy)methyl]imidazo[1,2-a]pyridine-3-carboxamide

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Technology Process of N-{5-[5-(3,3-difluorocyclobutyl)-1,2,4-oxadiazol-3-yl]-2-methylphenyl}-6-[(2-fluoroethoxy)methyl]imidazo[1,2-a]pyridine-3-carboxamide

There total 11 articles about N-{5-[5-(3,3-difluorocyclobutyl)-1,2,4-oxadiazol-3-yl]-2-methylphenyl}-6-[(2-fluoroethoxy)methyl]imidazo[1,2-a]pyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 371-62-0
2-fluoroethanol

: 1426448-28-3
N-{5-[5-(3,3-difluorocyclobutyl)-1,2,4-oxadiazol-3-yl]-2-methylphenyl}-6-(hydroxymethyl)imidazo[1,2-a]pyridine-3-carboxamide

: 1426448-74-9
N-{5-[5-(3,3-difluorocyclobutyl)-1,2,4-oxadiazol-3-yl]-2-methylphenyl}-6-[(2-fluoroethoxy)methyl]imidazo[1,2-a]pyridine-3-carboxamide

Guidance literature:: N-{5-[5-(3,3-difluorocyclobutyl)-1,2,4-oxadiazol-3-yl]-2-methylphenyl}-6-(hydroxymethyl)imidazo[1,2-a]pyridine-3-carboxamide; With methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.25h;

2-fluoroethanol; With potassium carbonate; at 120 ℃; for 0.333333h;

Reference yield:

: 1426136-06-2
ethyl 6-(((triisopropylsilyl)oxy)methyl)imidazo[1,2-a]pyridine-3-carboxylate

: 1426448-74-9
N-{5-[5-(3,3-difluorocyclobutyl)-1,2,4-oxadiazol-3-yl]-2-methylphenyl}-6-[(2-fluoroethoxy)methyl]imidazo[1,2-a]pyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium hydroxide / tetrahydrofuran; methanol; water / 2 h / 20 °C

2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0.25 h / 20 °C

3.1: pyridine / 0.33 h / 20 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h

5.1: methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.25 h / 20 °C

5.2: 0.33 h / 120 °C

With pyridine; oxalyl dichloride; tetrabutyl ammonium fluoride; methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water;

Reference yield:

: 936637-99-9
ethyl 6-(hydroxymethyl)imidazo[1,2-a]pyridine-3-carboxylate

: 1426448-74-9
N-{5-[5-(3,3-difluorocyclobutyl)-1,2,4-oxadiazol-3-yl]-2-methylphenyl}-6-[(2-fluoroethoxy)methyl]imidazo[1,2-a]pyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: 1H-imidazole; dmap / dichloromethane / 20 °C

2.1: lithium hydroxide / tetrahydrofuran; methanol; water / 2 h / 20 °C

3.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0.25 h / 20 °C

4.1: pyridine / 0.33 h / 20 °C

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h

6.1: methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.25 h / 20 °C

6.2: 0.33 h / 120 °C

With pyridine; 1H-imidazole; dmap; oxalyl dichloride; tetrabutyl ammonium fluoride; methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water;