(2R,3S,4aR,5aS,6aR,8S,9R,10aS,11aR,12aS)-9-Benzyloxy-8-(2-benzyloxy-ethyl)-3-(tert-butyl-dimethyl-silanyloxy)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5a,11a-dimethoxy-2-methyl-tetradecahydro-1,5,7,11-tetraoxa-naphthacene

Base Information

Chemical Name:(2R,3S,4aR,5aS,6aR,8S,9R,10aS,11aR,12aS)-9-Benzyloxy-8-(2-benzyloxy-ethyl)-3-(tert-butyl-dimethyl-silanyloxy)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5a,11a-dimethoxy-2-methyl-tetradecahydro-1,5,7,11-tetraoxa-naphthacene
CAS No.:476688-34-3
Molecular Formula:C₄₆H₇₄O₁₀Si₂
Molecular Weight:843.259
Hs Code.:

(2R,3S,4aR,5aS,6aR,8S,9R,10aS,11aR,12aS)-9-Benzyloxy-8-(2-benzyloxy-ethyl)-3-(tert-butyl-dimethyl-silanyloxy)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5a,11a-dimethoxy-2-methyl-tetradecahydro-1,5,7,11-tetraoxa-naphthacene

Synonyms:(2R,3S,4aR,5aS,6aR,8S,9R,10aS,11aR,12aS)-9-Benzyloxy-8-(2-benzyloxy-ethyl)-3-(tert-butyl-dimethyl-silanyloxy)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5a,11a-dimethoxy-2-methyl-tetradecahydro-1,5,7,11-tetraoxa-naphthacene

Suppliers and Price of (2R,3S,4aR,5aS,6aR,8S,9R,10aS,11aR,12aS)-9-Benzyloxy-8-(2-benzyloxy-ethyl)-3-(tert-butyl-dimethyl-silanyloxy)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5a,11a-dimethoxy-2-methyl-tetradecahydro-1,5,7,11-tetraoxa-naphthacene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2R,3S,4aR,5aS,6aR,8S,9R,10aS,11aR,12aS)-9-Benzyloxy-8-(2-benzyloxy-ethyl)-3-(tert-butyl-dimethyl-silanyloxy)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5a,11a-dimethoxy-2-methyl-tetradecahydro-1,5,7,11-tetraoxa-naphthacene

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2R,3S,4aR,5aS,6aR,8S,9R,10aS,11aR,12aS)-9-Benzyloxy-8-(2-benzyloxy-ethyl)-3-(tert-butyl-dimethyl-silanyloxy)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5a,11a-dimethoxy-2-methyl-tetradecahydro-1,5,7,11-tetraoxa-naphthacene

There total 20 articles about (2R,3S,4aR,5aS,6aR,8S,9R,10aS,11aR,12aS)-9-Benzyloxy-8-(2-benzyloxy-ethyl)-3-(tert-butyl-dimethyl-silanyloxy)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5a,11a-dimethoxy-2-methyl-tetradecahydro-1,5,7,11-tetraoxa-naphthacene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 476688-30-9
(4aR,6S,7R,8aS)-6-(2-Hydroxy-ethyl)-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-ol

: 476688-34-3
(2R,3S,4aR,5aS,6aR,8S,9R,10aS,11aR,12aS)-9-Benzyloxy-8-(2-benzyloxy-ethyl)-3-(tert-butyl-dimethyl-silanyloxy)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5a,11a-dimethoxy-2-methyl-tetradecahydro-1,5,7,11-tetraoxa-naphthacene

Guidance literature:: Multi-step reaction with 9 steps

1.1: 97 percent / NaH; n-Bu₄NI / tetrahydrofuran / 20 °C

2.1: 95 percent / CSA / methanol / 20 °C

3.1: 2,6-lutidine / CH₂Cl₂ / -78 °C

3.2: 73 percent / CH₂Cl₂ / -78 °C

4.1: 75 percent / t-BuLi; HMPA / tetrahydrofuran / -78 °C

5.1: CSA / methanol / 20 °C

6.1: 2,6-lutidine / CH₂Cl₂ / 0 °C

7.1: 73 percent / NaIO₄ / RuO₂ / acetonitrile; CCl₄; H₂O / 20 °C

8.1: 91 percent / CSA / methanol / 80 °C

9.1: 55 percent / 2,6-lutidine / CH₂Cl₂ / 0 °C

With 2,6-dimethylpyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; sodium periodate; camphor-10-sulfonic acid; tert.-butyl lithium; tetra-(n-butyl)ammonium iodide; sodium hydride; ruthenium(IV) oxide; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; water; acetonitrile;
DOI:10.1021/ol026804w

Reference yield:

: (2R,3S,5R,6S)-6-{4-[(2R,3S,5R,6S)-5-Benzyloxy-6-(2-benzyloxy-ethyl)-3-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-pyran-2-yl]-but-2-ynyl}-5-(tert-butyl-dimethyl-silanyloxy)-2-hydroxymethyl-2-methyl-tetrahydro-pyran-3-ol

: 476688-34-3
(2R,3S,4aR,5aS,6aR,8S,9R,10aS,11aR,12aS)-9-Benzyloxy-8-(2-benzyloxy-ethyl)-3-(tert-butyl-dimethyl-silanyloxy)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5a,11a-dimethoxy-2-methyl-tetradecahydro-1,5,7,11-tetraoxa-naphthacene

Guidance literature:: Multi-step reaction with 4 steps

1: 2,6-lutidine / CH₂Cl₂ / 0 °C

2: 73 percent / NaIO₄ / RuO₂ / acetonitrile; CCl₄; H₂O / 20 °C

3: 91 percent / CSA / methanol / 80 °C

4: 55 percent / 2,6-lutidine / CH₂Cl₂ / 0 °C

With 2,6-dimethylpyridine; sodium periodate; camphor-10-sulfonic acid; ruthenium(IV) oxide; In methanol; tetrachloromethane; dichloromethane; water; acetonitrile;
DOI:10.1021/ol026804w

Reference yield:

: 476688-24-1
C₅₆H₉₈O₈Si₄

: 476688-34-3
(2R,3S,4aR,5aS,6aR,8S,9R,10aS,11aR,12aS)-9-Benzyloxy-8-(2-benzyloxy-ethyl)-3-(tert-butyl-dimethyl-silanyloxy)-2-(tert-butyl-dimethyl-silanyloxymethyl)-5a,11a-dimethoxy-2-methyl-tetradecahydro-1,5,7,11-tetraoxa-naphthacene

Guidance literature:: Multi-step reaction with 3 steps

1: 73 percent / NaIO₄ / RuO₂ / acetonitrile; CCl₄; H₂O / 20 °C

2: 91 percent / CSA / methanol / 80 °C

3: 55 percent / 2,6-lutidine / CH₂Cl₂ / 0 °C

With 2,6-dimethylpyridine; sodium periodate; camphor-10-sulfonic acid; ruthenium(IV) oxide; In methanol; tetrachloromethane; dichloromethane; water; acetonitrile;
DOI:10.1021/ol026804w