8-methyl-3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl trifluoromethanesulfonate

Base Information

Chemical Name:8-methyl-3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl trifluoromethanesulfonate
CAS No.:1307813-74-6
Molecular Formula:C₂₃H₁₄F₆N₂O₅S
Molecular Weight:544.431
Hs Code.:

Synonyms:8-methyl-3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl trifluoromethanesulfonate

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Chemical Property of 8-methyl-3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl trifluoromethanesulfonate

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Technology Process of 8-methyl-3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl trifluoromethanesulfonate

There total 10 articles about 8-methyl-3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 358-23-6
trifluoromethylsulfonic anhydride

: 1307813-73-5
8-methyl-3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-ol

: 1307813-74-6
8-methyl-3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl trifluoromethanesulfonate

Guidance literature:: In pyridine; at 0 - 20 ℃;

Reference yield:

: 7063-99-2
ethyl 5-phenylisoxazole-3-carboxylate

: 1307813-74-6
8-methyl-3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 7 steps

1.1: trifluoroacetic acid; N-iodo-succinimide / 3.5 h / 20 °C

2.1: N,N,N,N,N,N-hexamethylphosphoric triamide / copper(l) iodide / N,N-dimethyl-formamide / 20 - 80 °C

3.1: lithium hydroxide monohydrate / water; methanol / 0.5 h / 20 °C

3.2: pH 1

4.1: diazomethyl-trimethyl-silane / dichloromethane; diethyl ether / 20 °C

5.1: lithium diisopropyl amide / tetrahydrofuran / 0 °C

5.2: 0.58 h / 0 °C

6.1: boron tribromide / dichloromethane / 0 - 20 °C

7.1: pyridine / 0 - 20 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; N-iodo-succinimide; lithium hydroxide monohydrate; boron tribromide; trifluoroacetic acid; lithium diisopropyl amide; diazomethyl-trimethyl-silane; copper(l) iodide; In tetrahydrofuran; pyridine; methanol; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 536-74-3
phenylacetylene

: 1307813-74-6
8-methyl-3-(5-phenyl-4-(trifluoromethyl)isoxazol-3-yl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 8 steps

1.1: triethylamine / diethyl ether / 3 h / 20 °C

2.1: trifluoroacetic acid; N-iodo-succinimide / 3.5 h / 20 °C

3.1: N,N,N,N,N,N-hexamethylphosphoric triamide / copper(l) iodide / N,N-dimethyl-formamide / 20 - 80 °C

4.1: lithium hydroxide monohydrate / water; methanol / 0.5 h / 20 °C

4.2: pH 1

5.1: diazomethyl-trimethyl-silane / dichloromethane; diethyl ether / 20 °C

6.1: lithium diisopropyl amide / tetrahydrofuran / 0 °C

6.2: 0.58 h / 0 °C

7.1: boron tribromide / dichloromethane / 0 - 20 °C

8.1: pyridine / 0 - 20 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; N-iodo-succinimide; lithium hydroxide monohydrate; boron tribromide; triethylamine; trifluoroacetic acid; lithium diisopropyl amide; diazomethyl-trimethyl-silane; copper(l) iodide; In tetrahydrofuran; pyridine; methanol; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide;