4-[1-(4-Chloro-phenyl)-5-fluoro-3-methyl-2-oxo-2,3-dihydro-1H-indol-3-ylamino]-N-hydroxy-benzamide

Base Information

Chemical Name:4-[1-(4-Chloro-phenyl)-5-fluoro-3-methyl-2-oxo-2,3-dihydro-1H-indol-3-ylamino]-N-hydroxy-benzamide
CAS No.:1390618-52-6
Molecular Formula:C₂₂H₁₇ClFN₃O₃
Molecular Weight:425.847
Hs Code.:

Synonyms:4-[1-(4-Chloro-phenyl)-5-fluoro-3-methyl-2-oxo-2,3-dihydro-1H-indol-3-ylamino]-N-hydroxy-benzamide

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Chemical Property of 4-[1-(4-Chloro-phenyl)-5-fluoro-3-methyl-2-oxo-2,3-dihydro-1H-indol-3-ylamino]-N-hydroxy-benzamide

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Technology Process of 4-[1-(4-Chloro-phenyl)-5-fluoro-3-methyl-2-oxo-2,3-dihydro-1H-indol-3-ylamino]-N-hydroxy-benzamide

There total 8 articles about 4-[1-(4-Chloro-phenyl)-5-fluoro-3-methyl-2-oxo-2,3-dihydro-1H-indol-3-ylamino]-N-hydroxy-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1390618-92-4
4-[1-(4-chloro-phenyl)-5-fluoro-3-methyl-2-oxo-2,3-dihydro-1H-indol-3-ylamino]-benzoic acid methyl ester

: 1390618-52-6
4-[1-(4-Chloro-phenyl)-5-fluoro-3-methyl-2-oxo-2,3-dihydro-1H-indol-3-ylamino]-N-hydroxy-benzamide

Guidance literature:: With hydroxylamine; potassium hydroxide; In methanol; water; at 20 ℃; for 3h;

Reference yield:

: 56341-41-4
5-fluoroindol-2(3H)-one

: 1390618-52-6
4-[1-(4-Chloro-phenyl)-5-fluoro-3-methyl-2-oxo-2,3-dihydro-1H-indol-3-ylamino]-N-hydroxy-benzamide

Guidance literature:: Multi-step reaction with 6 steps

1: tetrahydrofuran / 4 h / 20 °C

2: methanol; sodium tetrahydroborate / 3 h / 0 - 20 °C

3: pyridinium hydrobromide perbromide / water; tert-butyl alcohol / 2 h / 20 °C

4: triethylamine / N,N-dimethyl-formamide / 2 h / 20 °C

5: potassium carbonate / copper(l) iodide; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane / N,N-dimethyl-formamide / 90 °C

6: hydroxylamine; potassium hydroxide / methanol; water / 3 h / 20 °C

With methanol; sodium tetrahydroborate; pyridinium hydrobromide perbromide; hydroxylamine; potassium carbonate; triethylamine; potassium hydroxide; copper(l) iodide; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 1390618-89-9
(E)-3-((dimethylamino)methylene)-5-fluoroindolin-2-one

: 1390618-52-6
4-[1-(4-Chloro-phenyl)-5-fluoro-3-methyl-2-oxo-2,3-dihydro-1H-indol-3-ylamino]-N-hydroxy-benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: methanol; sodium tetrahydroborate / 3 h / 0 - 20 °C

2: pyridinium hydrobromide perbromide / water; tert-butyl alcohol / 2 h / 20 °C

3: triethylamine / N,N-dimethyl-formamide / 2 h / 20 °C

4: potassium carbonate / copper(l) iodide; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane / N,N-dimethyl-formamide / 90 °C

5: hydroxylamine; potassium hydroxide / methanol; water / 3 h / 20 °C

With methanol; sodium tetrahydroborate; pyridinium hydrobromide perbromide; hydroxylamine; potassium carbonate; triethylamine; potassium hydroxide; copper(l) iodide; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane; In methanol; water; N,N-dimethyl-formamide; tert-butyl alcohol;