(4S)-4-isopropyl-2-[(2R,E)-2-phenyl-4-(trimethylsilyl)-3-butenyl]-4,5-dihydro-1,3-oxazole

Base Information

Chemical Name:(4S)-4-isopropyl-2-[(2R,E)-2-phenyl-4-(trimethylsilyl)-3-butenyl]-4,5-dihydro-1,3-oxazole
CAS No.:675855-21-7
Molecular Formula:C₁₉H₂₉NOSi
Molecular Weight:315.531
Hs Code.:

Synonyms:(4S)-4-isopropyl-2-[(2R,E)-2-phenyl-4-(trimethylsilyl)-3-butenyl]-4,5-dihydro-1,3-oxazole

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Chemical Property of (4S)-4-isopropyl-2-[(2R,E)-2-phenyl-4-(trimethylsilyl)-3-butenyl]-4,5-dihydro-1,3-oxazole

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Technology Process of (4S)-4-isopropyl-2-[(2R,E)-2-phenyl-4-(trimethylsilyl)-3-butenyl]-4,5-dihydro-1,3-oxazole

There total 3 articles about (4S)-4-isopropyl-2-[(2R,E)-2-phenyl-4-(trimethylsilyl)-3-butenyl]-4,5-dihydro-1,3-oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1066-54-2
trimethylsilylacetylene

: (4S,E)-4-isopropyl-2-(2-phenylethenyl)-4,5-dihydro-1,3-oxazole

: (4S)-4-isopropyl-2-[(2S,E)-2-phenyl-4-(trimethylsilyl)-3-butenyl]-4,5-dihydro-1,3-oxazole

: 675855-21-7
(4S)-4-isopropyl-2-[(2R,E)-2-phenyl-4-(trimethylsilyl)-3-butenyl]-4,5-dihydro-1,3-oxazole

Guidance literature:: (4S,E)-4-isopropyl-2-(2-phenylethenyl)-4,5-dihydro-1,3-oxazole; With titanium(IV) isopropylate; isopropylmagnesium chloride; In diethyl ether; at -20 ℃; for 16h;

trimethylsilylacetylene; In diethyl ether; at -20 ℃; for 2h;

With water; In diethyl ether; Title compound not separated from byproducts;
DOI:10.1002/anie.200352769

Reference yield:

: 2026-48-4,473-75-6
(S)-valinol

: 675855-21-7
(4S)-4-isopropyl-2-[(2R,E)-2-phenyl-4-(trimethylsilyl)-3-butenyl]-4,5-dihydro-1,3-oxazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: aq. Na₂CO₃ / CH₂Cl₂

1.2: 68 percent / Et₃N; Methanesulfonyl chloride / CH₂Cl₂ / 12 h / 20 °C

2.1: Ti(O-i-Pr)4; i-PrMgCl / diethyl ether / 16 h / -20 °C

2.2: diethyl ether / 2 h / -20 °C

2.3: H₂O / diethyl ether

With titanium(IV) isopropylate; isopropylmagnesium chloride; sodium carbonate; In diethyl ether; dichloromethane;
DOI:10.1002/anie.200352769

Reference yield:

: 102-92-1,17082-09-6
Cinnamoyl chloride

: 675855-21-7
(4S)-4-isopropyl-2-[(2R,E)-2-phenyl-4-(trimethylsilyl)-3-butenyl]-4,5-dihydro-1,3-oxazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: aq. Na₂CO₃ / CH₂Cl₂

1.2: 68 percent / Et₃N; Methanesulfonyl chloride / CH₂Cl₂ / 12 h / 20 °C

2.1: Ti(O-i-Pr)4; i-PrMgCl / diethyl ether / 16 h / -20 °C

2.2: diethyl ether / 2 h / -20 °C

2.3: H₂O / diethyl ether

With titanium(IV) isopropylate; isopropylmagnesium chloride; sodium carbonate; In diethyl ether; dichloromethane;
DOI:10.1002/anie.200352769