isopropyl-({[6-(4-trifluoromethylphenyl)pyrimidin-4-ylmethyl]carbamoyl}methyl)carbamic acid tert-butyl ester

Base Information

Chemical Name:isopropyl-({[6-(4-trifluoromethylphenyl)pyrimidin-4-ylmethyl]carbamoyl}methyl)carbamic acid tert-butyl ester
CAS No.:1590397-88-8
Molecular Formula:C₂₂H₂₇F₃N₄O₃
Molecular Weight:452.477
Hs Code.:

Synonyms:isopropyl-({[6-(4-trifluoromethylphenyl)pyrimidin-4-ylmethyl]carbamoyl}methyl)carbamic acid tert-butyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of isopropyl-({[6-(4-trifluoromethylphenyl)pyrimidin-4-ylmethyl]carbamoyl}methyl)carbamic acid tert-butyl ester

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Technology Process of isopropyl-({[6-(4-trifluoromethylphenyl)pyrimidin-4-ylmethyl]carbamoyl}methyl)carbamic acid tert-butyl ester

There total 1 articles about isopropyl-({[6-(4-trifluoromethylphenyl)pyrimidin-4-ylmethyl]carbamoyl}methyl)carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: [6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl]methanamine hydrochloride

: 154509-63-4
2-(tert-butoxycarbonyl(isopropyl)amino)acetic acid

: 1590397-88-8
isopropyl-({[6-(4-trifluoromethylphenyl)pyrimidin-4-ylmethyl]carbamoyl}methyl)carbamic acid tert-butyl ester

Guidance literature:: With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 2h;

Reference yield:

: 1590397-88-8
isopropyl-({[6-(4-trifluoromethylphenyl)pyrimidin-4-ylmethyl]carbamoyl}methyl)carbamic acid tert-butyl ester

: 1590397-89-9
2-isopropylamino-N-[6-(4-trifluoromethylphenyl)pyrimidin-4-ylmethyl]acetamide

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 2h;

Reference yield:

: 1590397-88-8
isopropyl-({[6-(4-trifluoromethylphenyl)pyrimidin-4-ylmethyl]carbamoyl}methyl)carbamic acid tert-butyl ester

: 1590397-38-8
2-[isopropyl-(pyridine-3-sulfonyl)-amino]-N-[6-(4-trifluoromethylphenyl)-pyrimidin-4-ylmethyl]-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane;