(R)-2-[4-(3-phenyl-prop-2-ynyloxy)-phenoxymethyl]-pyrrolidine hydrochloride

Base Information

Chemical Name:(R)-2-[4-(3-phenyl-prop-2-ynyloxy)-phenoxymethyl]-pyrrolidine hydrochloride
CAS No.:1006382-10-0
Molecular Formula:C₂₀H₂₁NO₂*ClH
Molecular Weight:343.853
Hs Code.:

Synonyms:(R)-2-[4-(3-phenyl-prop-2-ynyloxy)-phenoxymethyl]-pyrrolidine hydrochloride

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Chemical Property of (R)-2-[4-(3-phenyl-prop-2-ynyloxy)-phenoxymethyl]-pyrrolidine hydrochloride

Chemical Property:

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Technology Process of (R)-2-[4-(3-phenyl-prop-2-ynyloxy)-phenoxymethyl]-pyrrolidine hydrochloride

There total 6 articles about (R)-2-[4-(3-phenyl-prop-2-ynyloxy)-phenoxymethyl]-pyrrolidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: (R)-2-[4-(3-phenyl-prop-2-ynyloxy)-phenoxymethyl]-pyrrolidine-1-carboxylic acid tert-butyl ester

: 1006382-10-0
(R)-2-[4-(3-phenyl-prop-2-ynyloxy)-phenoxymethyl]-pyrrolidine hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 2h;

Reference yield:

: 1006382-20-2
(R)-2-(4-prop-2-ynyloxy-phenoxymethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

: 1006382-10-0
(R)-2-[4-(3-phenyl-prop-2-ynyloxy)-phenoxymethyl]-pyrrolidine hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: pyrrolidine; water / palladium dichloride / 24 h / 50 °C

2: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

With pyrrolidine; hydrogenchloride; water; palladium dichloride; In 1,4-dioxane;

Reference yield:

: 929918-02-5
(R)-2-(4-hydroxy-phenoxymethyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

: 1006382-10-0
(R)-2-[4-(3-phenyl-prop-2-ynyloxy)-phenoxymethyl]-pyrrolidine hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 54 h / 20 - 50 °C

2: pyrrolidine; water / palladium dichloride / 24 h / 50 °C

3: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

With pyrrolidine; hydrogenchloride; water; potassium carbonate; palladium dichloride; In 1,4-dioxane; N,N-dimethyl-formamide;