Technology Process of 5-((5-methoxypyridin-3-yl)methyl)-2-phenylpyridine
There total 4 articles about 5-((5-methoxypyridin-3-yl)methyl)-2-phenylpyridine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate;
In
1,2-dimethoxyethane; ethanol; water;
at 150 ℃;
for 0.333333h;
under 13501.4 Torr;
Inert atmosphere;
Reflux;
Microwave irradiation;
DOI:10.1021/jm400240r
- Guidance literature:
-
Multi-step reaction with 2 steps
1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / Reflux
2: caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / ethanol; water; 1,2-dimethoxyethane / 0.33 h / 150 °C / 13501.4 Torr / Inert atmosphere; Reflux; Microwave irradiation
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-Bromosuccinimide; caesium carbonate; dibenzoyl peroxide;
In
tetrachloromethane; 1,2-dimethoxyethane; ethanol; water;
1: |Wohl-Ziegler Bromination / 2: |Suzuki Coupling;
DOI:10.1021/jm400240r
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sodium carbonate; tetrakis(triphenylphosphine) palladium(0) / toluene; ethanol; water / 4 h / Inert atmosphere; Reflux
2: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / Reflux
3: caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / ethanol; water; 1,2-dimethoxyethane / 0.33 h / 150 °C / 13501.4 Torr / Inert atmosphere; Reflux; Microwave irradiation
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium(0); sodium carbonate; caesium carbonate; dibenzoyl peroxide;
In
tetrachloromethane; 1,2-dimethoxyethane; ethanol; water; toluene;
1: |Suzuki Coupling / 2: |Wohl-Ziegler Bromination / 3: |Suzuki Coupling;
DOI:10.1021/jm400240r
