(E)-3-(benzyloxy)methoxy-6-(tert-butyldimethylsilyloxymethyl)-2-trimethylsilylocta-1,6-diene

Base Information

Chemical Name:(E)-3-(benzyloxy)methoxy-6-(tert-butyldimethylsilyloxymethyl)-2-trimethylsilylocta-1,6-diene
CAS No.:886976-23-4
Molecular Formula:C₂₆H₄₆O₃Si₂
Molecular Weight:462.82
Hs Code.:

Synonyms:(E)-3-(benzyloxy)methoxy-6-(tert-butyldimethylsilyloxymethyl)-2-trimethylsilylocta-1,6-diene

Suppliers and Price of (E)-3-(benzyloxy)methoxy-6-(tert-butyldimethylsilyloxymethyl)-2-trimethylsilylocta-1,6-diene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (E)-3-(benzyloxy)methoxy-6-(tert-butyldimethylsilyloxymethyl)-2-trimethylsilylocta-1,6-diene

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (E)-3-(benzyloxy)methoxy-6-(tert-butyldimethylsilyloxymethyl)-2-trimethylsilylocta-1,6-diene

There total 8 articles about (E)-3-(benzyloxy)methoxy-6-(tert-butyldimethylsilyloxymethyl)-2-trimethylsilylocta-1,6-diene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 886976-30-3
(E)-6-(tert-butyldimethylsilyloxymethyl)-3-hydroxy-2-trimethylsilyl-octa-1,6-diene

: 3587-60-8
Benzyloxymethyl chloride

: 886976-23-4
(E)-3-(benzyloxy)methoxy-6-(tert-butyldimethylsilyloxymethyl)-2-trimethylsilylocta-1,6-diene

Guidance literature:: With tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; for 2h; Heating;
DOI:10.1021/ol0602506

Reference yield:

: 886976-20-1
4-(diethoxymethyl)-hex-4-enoic acid ethyl ester

: 886976-23-4
(E)-3-(benzyloxy)methoxy-6-(tert-butyldimethylsilyloxymethyl)-2-trimethylsilylocta-1,6-diene

Guidance literature:: Multi-step reaction with 7 steps

1.1: 3.7293 g / water; oxalic acid / methanol / 24 h / 20 °C

2.1: 94 percent / sodium borohydride / methanol / 0.5 h / 0 °C

3.1: 87 percent / imidazole / CH₂Cl₂ / 1 h / 0 °C

4.1: 89 percent / lithium aluminum hydride / tetrahydrofuran / 0.75 h / -78 - 0 °C

5.1: 97 percent / oxalyl chloride; dimethyl sulfoxide; triethylamine / CH₂Cl₂ / 0.92 h / -78 - 20 °C

6.1: tert-butyllithium / diethyl ether; pentane / 2.5 h / -78 °C

6.2: diethyl ether; pentane / 0.5 h / -78 - 0 °C

7.1: 86 percent / tetrabutylammonium iodide; N,N-diisopropylethylamine / tetrahydrofuran / 2 h / Heating

With 1H-imidazole; sodium tetrahydroborate; lithium aluminium tetrahydride; oxalyl dichloride; water; tert.-butyl lithium; oxalic acid; tetra-(n-butyl)ammonium iodide; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; pentane; 5.1: Swern oxidation;
DOI:10.1021/ol0602506

Reference yield:

: 886976-22-3
4-(tert-butyl-dimethyl-silanyloxymethyl)-hex-4-enal

: 886976-23-4
(E)-3-(benzyloxy)methoxy-6-(tert-butyldimethylsilyloxymethyl)-2-trimethylsilylocta-1,6-diene

Guidance literature:: Multi-step reaction with 2 steps

1.1: tert-butyllithium / diethyl ether; pentane / 2.5 h / -78 °C

1.2: diethyl ether; pentane / 0.5 h / -78 - 0 °C

2.1: 86 percent / tetrabutylammonium iodide; N,N-diisopropylethylamine / tetrahydrofuran / 2 h / Heating

With tert.-butyl lithium; tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; diethyl ether; pentane;
DOI:10.1021/ol0602506