N₂-methyl-N₂-[(2-nitrophenyl)sulfonyl]-N-(triphenylmethyl)-L-asparagine methyl ester

Base Information

• Chemical Name: N₂-methyl-N₂-[(2-nitrophenyl)sulfonyl]-N-(triphenylmethyl)-L-asparagine methyl ester
• CAS No.: 856865-75-3
• Molecular Formula: C₃₁H₂₉N₃O₇S
• Molecular Weight: 587.653

Synonyms:N₂-methyl-N₂-[(2-nitrophenyl)sulfonyl]-N-(triphenylmethyl)-L-asparagine methyl ester

Chemical Property of N₂-methyl-N₂-[(2-nitrophenyl)sulfonyl]-N-(triphenylmethyl)-L-asparagine methyl ester

Chemical Property:

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Technology Process of N₂-methyl-N₂-[(2-nitrophenyl)sulfonyl]-N-(triphenylmethyl)-L-asparagine methyl ester

There total 3 articles about N₂-methyl-N₂-[(2-nitrophenyl)sulfonyl]-N-(triphenylmethyl)-L-asparagine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methyl (2S)-2-(o-nitrobenzenesulfonylamino)-4-oxo-4-(tritylamino)butanoate (856865-59-3) + dimethyl sulfate (77-78-1) → N2-methyl-N2-[(2-nitrophenyl)sulfonyl]-N-(triphenylmethyl)-L-asparagine methyl ester (856865-75-3)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; at 0 ℃; for 0.25h;

DOI:10.1021/jo050477z

Reference yield:

2-amino-N-trityl-succinamic acid methyl ester; hydrochloride → N2-methyl-N2-[(2-nitrophenyl)sulfonyl]-N-(triphenylmethyl)-L-asparagine methyl ester (856865-75-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / triethylamine / CH₂Cl₂

2: 99 percent / 1,8-diazabicyclo[5.4.0]undec-7-ene / dimethylformamide / 0.25 h / 0 °C

With 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jo050477z

Reference yield:

2-Nitrobenzenesulfonyl chloride (1694-92-4) → N2-methyl-N2-[(2-nitrophenyl)sulfonyl]-N-(triphenylmethyl)-L-asparagine methyl ester (856865-75-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / triethylamine / CH₂Cl₂

2: 99 percent / 1,8-diazabicyclo[5.4.0]undec-7-ene / dimethylformamide / 0.25 h / 0 °C

With 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jo050477z

upstream raw materials:

methyl (2S)-2-(o-nitrobenzenesulfonylamino)-4-oxo-4-(tritylamino)butanoate

dimethyl sulfate

2-Nitrobenzenesulfonyl chloride

Downstream raw materials:

C₄₃H₄₁N₃O₇

N-α-methyl-N-α-(o-nitrobenzenesulfonyl)-N-β-trityl-L-asparagine

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