4-Amino-1,1,1-trifluorobutan-2-ol

Base Information

• Chemical Name: 4-Amino-1,1,1-trifluorobutan-2-ol
• CAS No.: 57165-84-1
• Molecular Formula: C₄H₈F₃NO
• Molecular Weight: 143.109
• European Community (EC) Number: 816-727-9
• Mol file: 57165-84-1.mol

Synonyms:4-amino-1,1,1-trifluorobutan-2-ol;57165-84-1;4-amino-2-hydroxy-1,1,1-trifluorobutane;SCHEMBL5181554;MFCD12047592;AKOS009945127;SB84523;4amino-2-hydroxy-1,1,1-trifluorobutane;BS-13094;CS-0051051;EN300-73252;P11360;A869744;Z445924774

Chemical Property of 4-Amino-1,1,1-trifluorobutan-2-ol

Chemical Property:

• XLogP3: 0.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 2
• Exact Mass: 143.05579836
• Heavy Atom Count: 9
• Complexity: 82.4

Purity/Quality:

97% ^*data from raw suppliers

4-amino-1,1,1-trifluorobutan-2-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C(CN)C(C(F)(F)F)O

Technology Process of 4-Amino-1,1,1-trifluorobutan-2-ol

There total 3 articles about 4-Amino-1,1,1-trifluorobutan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.43%

4,4,4-trifluoro-3-hydroxybutanamide (453-34-9) → 1-amino-3-hydroxy-4,4,4-trifluorobutane (57165-84-1)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 16h; Cooling with ice;

Reference yield:

N-(1,1,1-trifluoro-2-hydroxy-4-amino-N-butyl)phthalimide (1181778-59-5) → 1-amino-3-hydroxy-4,4,4-trifluorobutane (57165-84-1)

Guidance literature:

With hydrazine; In ethanol; Reflux;

DOI:10.1021/ja9033236

Reference yield:

3-hydroxy-4,4,4-trifluorobutyronitrile (57165-85-2) → 1-amino-3-hydroxy-4,4,4-trifluorobutane (57165-84-1)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether;

DOI:10.1021/jm00245a012

upstream raw materials:

3-hydroxy-4,4,4-trifluorobutyronitrile

N-(1,1,1-trifluoro-2-hydroxy-4-amino-N-butyl)phthalimide

4,4,4-trifluoro-3-hydroxybutanamide

Downstream raw materials:

bis-(2-chloro-ethyl)-(2-oxo-6-trifluoromethyl-2λ⁵-[1,3,2]oxazaphosphinan-2-yl)-amine

diethyl-(2-oxo-6c-trifluoromethyl-2λ⁵-[1,3,2]oxazaphosphinan-2r-yl)-amine

2-(Diethylamino)tetrahydro-6-trifluormethyl-2H-1,3,2-oxazaphosphorin-2-oxid

4-[bis-[[3-(trifluoromethoxy)phenyl]methyl]amino]-1,1,1-trifluoro-2-butanol

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