N-Z-L-valyl-L-phenylalanyl-L-glutamyl(γ-methyl ester)-L-phenylalanyl-L-valyl-L-proline methyl ester

Base Information

Chemical Name:N-Z-L-valyl-L-phenylalanyl-L-glutamyl(γ-methyl ester)-L-phenylalanyl-L-valyl-L-proline methyl ester
CAS No.:74757-98-5
Molecular Formula:C₄₈H₆₂N₆O₁₁
Molecular Weight:899.054
Hs Code.:

Synonyms:N-Z-L-valyl-L-phenylalanyl-L-glutamyl(γ-methyl ester)-L-phenylalanyl-L-valyl-L-proline methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-Z-L-valyl-L-phenylalanyl-L-glutamyl(γ-methyl ester)-L-phenylalanyl-L-valyl-L-proline methyl ester

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Technology Process of N-Z-L-valyl-L-phenylalanyl-L-glutamyl(γ-methyl ester)-L-phenylalanyl-L-valyl-L-proline methyl ester

There total 4 articles about N-Z-L-valyl-L-phenylalanyl-L-glutamyl(γ-methyl ester)-L-phenylalanyl-L-valyl-L-proline methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.6%

: 74757-94-1
N-Z-valyl-L-phenylalanyl-L-glutamic acid γ-methylester

: 74757-97-4
L-phenylalanyl-L-valyl-L-proline methyl ester acetate

: 74757-98-5
N-Z-L-valyl-L-phenylalanyl-L-glutamyl(γ-methyl ester)-L-phenylalanyl-L-valyl-L-proline methyl ester

Guidance literature:: With triethylamine; dicyclohexyl-carbodiimide; In chloroform; 0 deg C, 12 h, 20 deg C, 48 h;

Reference yield:

: 63-91-2,25191-15-5,658-69-5,67675-33-6
L-phenylalanine

: 74757-98-5
N-Z-L-valyl-L-phenylalanyl-L-glutamyl(γ-methyl ester)-L-phenylalanyl-L-valyl-L-proline methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1) isobutyl chloroformate, (C₂H₅)3N, 2) 1N aq. NaOH / 1) CHCl₃, -2-deg C, 20 min, 2) 0 deg C, 30 min, 20 deg C, 3 h

2: 1) isobutyl chloroformate, (C₂H₅)3N, 2) 1N aq. NaOH, (C₂H₅)3N / 1) CHCl₃, - 2 deg C, 20 min, 2) 0 deg C, 30 min, 20 deg C, 3 h

3: 91.6 percent / (C₂H₅)3N, dicyclohexylcarbodiimide / CHCl₃ / 0 deg C, 12 h, 20 deg C, 48 h

With sodium hydroxide; triethylamine; dicyclohexyl-carbodiimide; isobutyl chloroformate; In chloroform;

Reference yield:

: 1149-26-4
(S)-N-(benzyloxycarbonyl)valine

: 74757-98-5
N-Z-L-valyl-L-phenylalanyl-L-glutamyl(γ-methyl ester)-L-phenylalanyl-L-valyl-L-proline methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1) isobutyl chloroformate, (C₂H₅)3N, 2) 1N aq. NaOH / 1) CHCl₃, -2-deg C, 20 min, 2) 0 deg C, 30 min, 20 deg C, 3 h

2: 1) isobutyl chloroformate, (C₂H₅)3N, 2) 1N aq. NaOH, (C₂H₅)3N / 1) CHCl₃, - 2 deg C, 20 min, 2) 0 deg C, 30 min, 20 deg C, 3 h

3: 91.6 percent / (C₂H₅)3N, dicyclohexylcarbodiimide / CHCl₃ / 0 deg C, 12 h, 20 deg C, 48 h

With sodium hydroxide; triethylamine; dicyclohexyl-carbodiimide; isobutyl chloroformate; In chloroform;