(1S,3R)-2,2-dichloro-3-methyl-N-[(1S)-1-phenylethyl]cyclopropanecarboxamide

Base Information

Chemical Name:(1S,3R)-2,2-dichloro-3-methyl-N-[(1S)-1-phenylethyl]cyclopropanecarboxamide
CAS No.:1283688-45-8
Molecular Formula:C₁₃H₁₅Cl₂NO
Molecular Weight:272.174
Hs Code.:

Synonyms:(1S,3R)-2,2-dichloro-3-methyl-N-[(1S)-1-phenylethyl]cyclopropanecarboxamide

Suppliers and Price of (1S,3R)-2,2-dichloro-3-methyl-N-[(1S)-1-phenylethyl]cyclopropanecarboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1S,3R)-2,2-dichloro-3-methyl-N-[(1S)-1-phenylethyl]cyclopropanecarboxamide

Chemical Property:

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Technology Process of (1S,3R)-2,2-dichloro-3-methyl-N-[(1S)-1-phenylethyl]cyclopropanecarboxamide

There total 6 articles about (1S,3R)-2,2-dichloro-3-methyl-N-[(1S)-1-phenylethyl]cyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (1S,3R)-2,2-dichloro-3-methylcyclopropanecarboxylic acid chloride

: 2627-86-3
(S)-1-phenyl-ethylamine

: 1283688-45-8
(1S,3R)-2,2-dichloro-3-methyl-N-[(1S)-1-phenylethyl]cyclopropanecarboxamide

Guidance literature:: In dichloromethane; at 20 ℃; for 1h;
DOI:10.1016/j.tetasy.2010.12.014

Reference yield:

: isopropyl trans-2,2-dichloro-3-methylcyclopropanecarboxylate

: 1283688-45-8
(1S,3R)-2,2-dichloro-3-methyl-N-[(1S)-1-phenylethyl]cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: sulfuric acid; water / 12 h / Reflux

2: acetone / 12 h / 5 °C / Reflux

3: sulfuric acid / water

4: thionyl chloride / 3 h / Reflux

5: dichloromethane / 1 h / 20 °C

With thionyl chloride; sulfuric acid; water; In dichloromethane; water; acetone;
DOI:10.1016/j.tetasy.2010.12.014

Reference yield:

: trans-2,2-dichloro-3-methylcyclopropanecarboxylic acid

: 1283688-45-8
(1S,3R)-2,2-dichloro-3-methyl-N-[(1S)-1-phenylethyl]cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: acetone / 12 h / 5 °C / Reflux

2: sulfuric acid / water

3: thionyl chloride / 3 h / Reflux

4: dichloromethane / 1 h / 20 °C

With thionyl chloride; sulfuric acid; In dichloromethane; water; acetone;
DOI:10.1016/j.tetasy.2010.12.014