2-(2-bromo-4-hydroxy-5-methoxyphenyl)-5-methoxy-4-methylnicotinic acid ethyl ester

Base Information

Chemical Name:2-(2-bromo-4-hydroxy-5-methoxyphenyl)-5-methoxy-4-methylnicotinic acid ethyl ester
CAS No.:161196-82-3
Molecular Formula:C₁₇H₁₈BrNO₅
Molecular Weight:396.238
Hs Code.:

Synonyms:2-(2-bromo-4-hydroxy-5-methoxyphenyl)-5-methoxy-4-methylnicotinic acid ethyl ester

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Chemical Property of 2-(2-bromo-4-hydroxy-5-methoxyphenyl)-5-methoxy-4-methylnicotinic acid ethyl ester

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Technology Process of 2-(2-bromo-4-hydroxy-5-methoxyphenyl)-5-methoxy-4-methylnicotinic acid ethyl ester

There total 4 articles about 2-(2-bromo-4-hydroxy-5-methoxyphenyl)-5-methoxy-4-methylnicotinic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 161196-92-5
2-<2-bromo-5-methoxy-4-(methoxymethyloxy)phenyl>-5-methoxy-4-methylnicotinic acid ethyl ester

: 161196-82-3
2-(2-bromo-4-hydroxy-5-methoxyphenyl)-5-methoxy-4-methylnicotinic acid ethyl ester

Guidance literature:: With hydrogenchloride; In ethanol; for 3h; Heating;
DOI:10.1002/ardp.19943271202

Reference yield:

: 14719-12-1,14748-54-0
3-chloro-2-methoxy-but-2-enal

: 161196-82-3
2-(2-bromo-4-hydroxy-5-methoxyphenyl)-5-methoxy-4-methylnicotinic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 48 percent / Et₃N, conc. HCl / ethanol / 3 h / Heating

2: 95 percent / conc. HCl / ethanol / 3 h / Heating

With hydrogenchloride; triethylamine; In ethanol;
DOI:10.1002/ardp.19943271202

Reference yield:

: 2-bromo-4-(methoxymethyloxy)-5-methoxybenzonitrile

: 161196-82-3
2-(2-bromo-4-hydroxy-5-methoxyphenyl)-5-methoxy-4-methylnicotinic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) Zn / 1.) THF, 2.) THF

2: 48 percent / Et₃N, conc. HCl / ethanol / 3 h / Heating

3: 95 percent / conc. HCl / ethanol / 3 h / Heating

With hydrogenchloride; triethylamine; zinc; In ethanol;
DOI:10.1002/ardp.19943271202