Dimethyl (+)-6-<2-(tert-butyldiphenylsilyloxy)ethyl>-3-(methoxymethoxy)piperidine-1,2-dicarboxylate

Base Information

Chemical Name:Dimethyl (+)-6-<2-(tert-butyldiphenylsilyloxy)ethyl>-3-(methoxymethoxy)piperidine-1,2-dicarboxylate
CAS No.:194227-99-1
Molecular Formula:C₂₉H₄₁NO₇Si
Molecular Weight:543.733
Hs Code.:

Synonyms:Dimethyl (+)-6-<2-(tert-butyldiphenylsilyloxy)ethyl>-3-(methoxymethoxy)piperidine-1,2-dicarboxylate

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Chemical Property of Dimethyl (+)-6-<2-(tert-butyldiphenylsilyloxy)ethyl>-3-(methoxymethoxy)piperidine-1,2-dicarboxylate

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Technology Process of Dimethyl (+)-6-<2-(tert-butyldiphenylsilyloxy)ethyl>-3-(methoxymethoxy)piperidine-1,2-dicarboxylate

There total 5 articles about Dimethyl (+)-6-<2-(tert-butyldiphenylsilyloxy)ethyl>-3-(methoxymethoxy)piperidine-1,2-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 144463-12-7
Dimethyl (+)-3-acetoxy-6-(2-hydroxyethyl)piperidine-1,2-dicarboxylate

: 194227-99-1
Dimethyl (+)-6-<2-(tert-butyldiphenylsilyloxy)ethyl>-3-(methoxymethoxy)piperidine-1,2-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / Et₃N, DMAP / CH₂Cl₂ / 15 h / Ambient temperature

2: K₂CO₃ / methanol / 0.83 h / Ambient temperature

3: i-Pr₂EtN / CHCl₃ / 2 h / Heating

With dmap; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; chloroform;

Reference yield:

: 144463-13-8
Dimethyl (+)-3-acetoxy-6-<2-(tert-butyldiphenylsilyloxy)ethyl>piperidine-1,2-dicarboxylate

: 194227-99-1
Dimethyl (+)-6-<2-(tert-butyldiphenylsilyloxy)ethyl>-3-(methoxymethoxy)piperidine-1,2-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: K₂CO₃ / methanol / 0.83 h / Ambient temperature

2: i-Pr₂EtN / CHCl₃ / 2 h / Heating

With potassium carbonate; N-ethyl-N,N-diisopropylamine; In methanol; chloroform;

Reference yield:

: (1S,5R,8R)-8-Acetoxy-2,2-dimethoxy-9-aza-bicyclo[3.3.1]nonane-9-carboxylic acid methyl ester

: 194227-99-1
Dimethyl (+)-6-<2-(tert-butyldiphenylsilyloxy)ethyl>-3-(methoxymethoxy)piperidine-1,2-dicarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 1) O₃, 2) NaBH₄ / -78 deg C to 0 deg C

2: 94 percent / Et₃N, DMAP

3: K₂CO₃ / methanol

4: i-Pr₂NEt

With dmap; sodium tetrahydroborate; potassium carbonate; ozone; triethylamine; N-ethyl-N,N-diisopropylamine; In methanol;
DOI:10.1016/S0040-4039(00)79101-5