3-[(5-Chloro-2-methoxyphenyl)methyl]-5-[4-fluoro-3-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2(3H)-one

Base Information

• Chemical Name: 3-[(5-Chloro-2-methoxyphenyl)methyl]-5-[4-fluoro-3-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2(3H)-one
• CAS No.: 202822-73-9
• Molecular Formula: C₁₇H₁₁ClF₄N₂O₃
• Molecular Weight: 402.733

Synonyms:3-[(5-Chloro-2-methoxyphenyl)methyl]-5-[4-fluoro-3-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2(3H)-one

Chemical Property of 3-[(5-Chloro-2-methoxyphenyl)methyl]-5-[4-fluoro-3-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2(3H)-one

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

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Technology Process of 3-[(5-Chloro-2-methoxyphenyl)methyl]-5-[4-fluoro-3-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2(3H)-one

There total 4 articles about 3-[(5-Chloro-2-methoxyphenyl)methyl]-5-[4-fluoro-3-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-(4-fluoro-3-trifluoromethyl-phenyl)-3H-[1,3,4]oxadiazol-2-one (220381-29-3) + 2-(bromomethyl)-4-chloro-1-methoxybenzene (58735-58-3) → 3-[(5-Chloro-2-methoxyphenyl)methyl]-5-[4-fluoro-3-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2(3H)-one (202822-73-9)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 60 ℃; for 18h;

DOI:10.1021/jm061006n

Reference yield:

4-fluoro-3-(trifluoromethyl)benzoic acid hydrazide → 3-[(5-Chloro-2-methoxyphenyl)methyl]-5-[4-fluoro-3-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2(3H)-one (202822-73-9)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / tetrahydrofuran / 18 h / 24 °C

2: NaH / dimethylformamide / 18 h / 60 °C

With sodium hydride; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/jm061006n

Reference yield:

4-fluoro-3-(trifluoromethyl)benzoic acid (67515-55-3) → 3-[(5-Chloro-2-methoxyphenyl)methyl]-5-[4-fluoro-3-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2(3H)-one (202822-73-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: iso-butylchloroformate; 4-methylmorpholine / tetrahydrofuran / 1.5 h / 20 °C

1.2: H₂N-NH₂ / tetrahydrofuran / 5 h

2.1: Et₃N / tetrahydrofuran / 18 h / 24 °C

3.1: NaH / dimethylformamide / 18 h / 60 °C

With 4-methyl-morpholine; sodium hydride; triethylamine; isobutyl chloroformate; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/jm061006n

upstream raw materials:

5-(4-fluoro-3-trifluoromethyl-phenyl)-3H-[1,3,4]oxadiazol-2-one

2-(bromomethyl)-4-chloro-1-methoxybenzene

4-fluoro-3-(trifluoromethyl)benzoic acid

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