trifluoromethanesulfonic acid 2-{[(3-cyclohex-1-enylprop-2-ynyl)trifluoromethanesulfonylamino]methyl}-6-(trimethylsilyl)phenyl ester

Base Information

Chemical Name:trifluoromethanesulfonic acid 2-{[(3-cyclohex-1-enylprop-2-ynyl)trifluoromethanesulfonylamino]methyl}-6-(trimethylsilyl)phenyl ester
CAS No.:866041-40-9
Molecular Formula:C₂₁H₂₅F₆NO₅S₂Si
Molecular Weight:577.641
Hs Code.:

trifluoromethanesulfonic acid 2-{[(3-cyclohex-1-enylprop-2-ynyl)trifluoromethanesulfonylamino]methyl}-6-(trimethylsilyl)phenyl ester

Synonyms:trifluoromethanesulfonic acid 2-{[(3-cyclohex-1-enylprop-2-ynyl)trifluoromethanesulfonylamino]methyl}-6-(trimethylsilyl)phenyl ester

Suppliers and Price of trifluoromethanesulfonic acid 2-{[(3-cyclohex-1-enylprop-2-ynyl)trifluoromethanesulfonylamino]methyl}-6-(trimethylsilyl)phenyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of trifluoromethanesulfonic acid 2-{[(3-cyclohex-1-enylprop-2-ynyl)trifluoromethanesulfonylamino]methyl}-6-(trimethylsilyl)phenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of trifluoromethanesulfonic acid 2-{[(3-cyclohex-1-enylprop-2-ynyl)trifluoromethanesulfonylamino]methyl}-6-(trimethylsilyl)phenyl ester

There total 6 articles about trifluoromethanesulfonic acid 2-{[(3-cyclohex-1-enylprop-2-ynyl)trifluoromethanesulfonylamino]methyl}-6-(trimethylsilyl)phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 866041-96-5
2-[(3-cyclohex-1-enylprop-2-ynylamino)methyl]-6-(trimethylsilyl)phenol

: 358-23-6
trifluoromethylsulfonic anhydride

: 866041-40-9
trifluoromethanesulfonic acid 2-{[(3-cyclohex-1-enylprop-2-ynyl)trifluoromethanesulfonylamino]methyl}-6-(trimethylsilyl)phenyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at -78 ℃; for 1h;
DOI:10.1021/ol051372l

Reference yield:

: 866041-35-2
2-[(prop-2-ynylamino)methyl]-6-(trimethylsilyl)phenol

: 866041-40-9
trifluoromethanesulfonic acid 2-{[(3-cyclohex-1-enylprop-2-ynyl)trifluoromethanesulfonylamino]methyl}-6-(trimethylsilyl)phenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / CuI; piperidine / (Ph₃P)2PdCl₂ / tetrahydrofuran / 1 h / 20 °C

2: 85 percent / (i-Pr₂)NEt / CH₂Cl₂ / 1 h / -78 °C

With piperidine; copper(l) iodide; N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; dichloromethane; 1: Sonogashira cross-coupling;
DOI:10.1021/ol051372l

Reference yield:

: 824-91-9
O-methoxymethylphenol

: 866041-40-9
trifluoromethanesulfonic acid 2-{[(3-cyclohex-1-enylprop-2-ynyl)trifluoromethanesulfonylamino]methyl}-6-(trimethylsilyl)phenyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-BuLi / tetrahydrofuran; hexane / 2 h / 0 °C

1.2: tetrahydrofuran; hexane / 0 - 20 °C

2.1: n-BuLi / tetrahydrofuran; hexane / 2 h / 0 °C

2.2: 87 percent / tetrahydrofuran; hexane / -78 - 20 °C

3.1: 97 percent / NaI; HCl / acetone; H₂O / 0.75 h / 55 °C

4.1: molecular sieves 3 Angstroem / methanol / 0.5 h / 20 °C

4.2: 83 percent / NaBH₄ / methanol / 1 h / 0 °C

5.1: 85 percent / CuI; piperidine / (Ph₃P)2PdCl₂ / tetrahydrofuran / 1 h / 20 °C

6.1: 85 percent / (i-Pr₂)NEt / CH₂Cl₂ / 1 h / -78 °C

With piperidine; hydrogenchloride; copper(l) iodide; n-butyllithium; 3 A molecular sieve; N-ethyl-N,N-diisopropylamine; sodium iodide; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; methanol; hexane; dichloromethane; water; acetone; 5.1: Sonogashira cross-coupling;
DOI:10.1021/ol051372l