(5S,1'R,6'R)-tert-butyl 5-[6-(methoxycarbonyl)-3-oxocyclohexyl]-2,2-dimethyl-3,1-oxazolidinecarboxylate

Base Information

Chemical Name:(5S,1'R,6'R)-tert-butyl 5-[6-(methoxycarbonyl)-3-oxocyclohexyl]-2,2-dimethyl-3,1-oxazolidinecarboxylate
CAS No.:167281-02-9
Molecular Formula:C₁₈H₂₉NO₆
Molecular Weight:355.431
Hs Code.:

Synonyms:(5S,1'R,6'R)-tert-butyl 5-[6-(methoxycarbonyl)-3-oxocyclohexyl]-2,2-dimethyl-3,1-oxazolidinecarboxylate

Suppliers and Price of (5S,1'R,6'R)-tert-butyl 5-[6-(methoxycarbonyl)-3-oxocyclohexyl]-2,2-dimethyl-3,1-oxazolidinecarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (5S,1'R,6'R)-tert-butyl 5-[6-(methoxycarbonyl)-3-oxocyclohexyl]-2,2-dimethyl-3,1-oxazolidinecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (5S,1'R,6'R)-tert-butyl 5-[6-(methoxycarbonyl)-3-oxocyclohexyl]-2,2-dimethyl-3,1-oxazolidinecarboxylate

There total 10 articles about (5S,1'R,6'R)-tert-butyl 5-[6-(methoxycarbonyl)-3-oxocyclohexyl]-2,2-dimethyl-3,1-oxazolidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 129483-65-4
(4S)-1,1-Dimethylethyl 4-<(E)-3'-methoxy-3'-oxo-1'-propenyl>-2,2-dimethyl-3-oxazolidinecarboxylate

: 167281-02-9
(5S,1'R,6'R)-tert-butyl 5-[6-(methoxycarbonyl)-3-oxocyclohexyl]-2,2-dimethyl-3,1-oxazolidinecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: aq. NaOH / tetrahydrofuran / 18 h / 0 - 20 °C

2.1: 8.90 g / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride, 4-dimethylaminopyridine / CH₂Cl₂ / 3 h / 20 °C

3.1: toluene / 75 h / 130 °C

3.2: NaOH / tetrahydrofuran; H₂O / 16 h / 0 - 20 °C

4.1: 1.00 g / methanol; diethyl ether

With dmap; sodium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; toluene; 1.1: Hydrolysis / 2.1: Esterification / 3.1: Diels-Alder reaction / 3.2: Hydrolysis / 4.1: Methylation;
DOI:10.1016/S0040-4020(98)00219-1

Reference yield:

: (S)-4-((E)-2-Carboxy-vinyl)-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

: 167281-02-9
(5S,1'R,6'R)-tert-butyl 5-[6-(methoxycarbonyl)-3-oxocyclohexyl]-2,2-dimethyl-3,1-oxazolidinecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 8.90 g / 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride, 4-dimethylaminopyridine / CH₂Cl₂ / 3 h / 20 °C

2.1: toluene / 75 h / 130 °C

2.2: NaOH / tetrahydrofuran; H₂O / 16 h / 0 - 20 °C

3.1: 1.00 g / methanol; diethyl ether

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; diethyl ether; dichloromethane; toluene; 1.1: Esterification / 2.1: Diels-Alder reaction / 2.2: Hydrolysis / 3.1: Methylation;
DOI:10.1016/S0040-4020(98)00219-1

Reference yield:

: 167281-00-7
(1'S,2E)-4-nitrophenyl 3-[5-(tert-butyl)oxycarbonyl-4,4-dimethyl-3,5-oxazolidinyl]prop-2-enoate

: 167281-02-9
(5S,1'R,6'R)-tert-butyl 5-[6-(methoxycarbonyl)-3-oxocyclohexyl]-2,2-dimethyl-3,1-oxazolidinecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: toluene / 72 h / 130 °C

1.2: NaOH / tetrahydrofuran; H₂O / 0 - 20 °C

2.1: 1.00 g / methanol; diethyl ether

In methanol; diethyl ether; toluene; 1.1: Diels-Alder reaction / 1.2: Hydrolysis / 2.1: Methylation;
DOI:10.1016/S0040-4020(98)00219-1