cyclobutanecarboxylic acid [4-(5-amino-1H-benzoimidazol-2-yl)-phenyl]-amide

Base Information

• Chemical Name: cyclobutanecarboxylic acid [4-(5-amino-1H-benzoimidazol-2-yl)-phenyl]-amide
• CAS No.: 1025958-95-5
• Molecular Formula: C₁₈H₁₈N₄O
• Molecular Weight: 306.367

Synonyms:cyclobutanecarboxylic acid [4-(5-amino-1H-benzoimidazol-2-yl)-phenyl]-amide

Chemical Property of cyclobutanecarboxylic acid [4-(5-amino-1H-benzoimidazol-2-yl)-phenyl]-amide

Chemical Property:

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Technology Process of cyclobutanecarboxylic acid [4-(5-amino-1H-benzoimidazol-2-yl)-phenyl]-amide

There total 4 articles about cyclobutanecarboxylic acid [4-(5-amino-1H-benzoimidazol-2-yl)-phenyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cyclobutanecarboxylic acid [4-(5-nitro-1H-benzoimidazol-2-yl)-phenyl]-amide (1026444-80-3) → cyclobutanecarboxylic acid [4-(5-amino-1H-benzoimidazol-2-yl)-phenyl]-amide (1025958-95-5)

Guidance literature:

With hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; at 80 ℃; for 16h;

DOI:10.1016/j.ejmech.2006.03.014

Reference yield:

4-amino-benzoic acid (150-13-0,159246-81-8,8014-65-1) → cyclobutanecarboxylic acid [4-(5-amino-1H-benzoimidazol-2-yl)-phenyl]-amide (1025958-95-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 47 percent / polyphosphoric acid / xylene / 60 - 150 °C

2: pyridine / 3 h / 20 °C

3: H₂ / Pd/C / methanol; tetrahydrofuran / 16 h / 80 °C

With pyridine; PPA; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; xylene;

DOI:10.1016/j.ejmech.2006.03.014

Reference yield:

4-Nitrophenylene-1,2-diamine (99-56-9) → cyclobutanecarboxylic acid [4-(5-amino-1H-benzoimidazol-2-yl)-phenyl]-amide (1025958-95-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 47 percent / polyphosphoric acid / xylene / 60 - 150 °C

2: pyridine / 3 h / 20 °C

3: H₂ / Pd/C / methanol; tetrahydrofuran / 16 h / 80 °C

With pyridine; PPA; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; xylene;

DOI:10.1016/j.ejmech.2006.03.014

upstream raw materials:

cyclobutanecarboxylic acid [4-(5-nitro-1H-benzoimidazol-2-yl)-phenyl]-amide

4-amino-benzoic acid

4-Nitrophenylene-1,2-diamine

5⁽⁶⁾-nitro 2-(4-aminophenyl)-1H-benzimidazole

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