phenyl[4'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]methanone

Base Information

• Chemical Name: phenyl[4'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]methanone
• CAS No.: 1009026-35-0
• Molecular Formula: C₂₀H₁₃F₃O
• Molecular Weight: 326.318
• Mol file: 1009026-35-0.mol

Synonyms:phenyl[4'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]methanone

Chemical Property of phenyl[4'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]methanone

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of phenyl[4'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]methanone

There total 7 articles about phenyl[4'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

p-PhC(O)C6H4NMe3(+)*I(-) (31688-74-1) + (4-(trifluoromethyl)phenyl)zinc(II) chloride (125102-17-2) → phenyl[4'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]methanone (1009026-35-0)

Guidance literature:

With C₃₈H₃₄Br₂N₄Ni₂P₂; potassium iodide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; at 65 ℃; for 12h; Reagent/catalyst; Inert atmosphere; Schlenk technique;

DOI:10.1021/om500452c

Reference yield: 92.0%

(4-bromophenyl)(phenyl)methanone (90-90-4) + 4-trifluoromethylphenylboronic acid (128796-39-4) → phenyl[4'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]methanone (1009026-35-0)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In tetrahydrofuran; water; at 75 ℃; for 24h; Inert atmosphere;

DOI:10.1021/acs.chemmater.5b01798

Reference yield: 90.0%

4-chlorobenzophenone (134-85-0) + (4-(trifluoromethyl)phenyl)zinc(II) chloride (125102-17-2) → phenyl[4'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]methanone (1009026-35-0)

Guidance literature:

With C₂₇H₂₂Cl₂N₃NiP; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; for 9h; Inert atmosphere; Schlenk technique; Heating;

DOI:10.1039/c2dt30886j

upstream raw materials:

para-diiodobenzene

4-Iodobenzotrifluoride

benzoyl chloride

4-benzoylphenyl methane sulfonate