{4-[(1R,3S)-3-{[(1R)-1-(Naphthalen-1-yl)ethyl]amino}cyclopentyl]phenoxy}acetic acid hydrochloride

Base Information

Chemical Name:{4-[(1R,3S)-3-{[(1R)-1-(Naphthalen-1-yl)ethyl]amino}cyclopentyl]phenoxy}acetic acid hydrochloride
CAS No.:1211471-88-3
Molecular Formula:C₂₅H₂₇NO₃*ClH
Molecular Weight:425.955
Hs Code.:

Synonyms:{4-[(1R,3S)-3-{[(1R)-1-(Naphthalen-1-yl)ethyl]amino}cyclopentyl]phenoxy}acetic acid hydrochloride

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Chemical Property of {4-[(1R,3S)-3-{[(1R)-1-(Naphthalen-1-yl)ethyl]amino}cyclopentyl]phenoxy}acetic acid hydrochloride

Chemical Property:

Purity/Quality:

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Technology Process of {4-[(1R,3S)-3-{[(1R)-1-(Naphthalen-1-yl)ethyl]amino}cyclopentyl]phenoxy}acetic acid hydrochloride

There total 4 articles about {4-[(1R,3S)-3-{[(1R)-1-(Naphthalen-1-yl)ethyl]amino}cyclopentyl]phenoxy}acetic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1157579-92-4
{4-[(1R,3S)-3-{[(1R)-1-(naphthalen-1-yl)ethyl]amino}cyclopentyl]phenoxy}acetic acid

: 1211471-88-3
{4-[(1R,3S)-3-{[(1R)-1-(Naphthalen-1-yl)ethyl]amino}cyclopentyl]phenoxy}acetic acid hydrochloride

Guidance literature:: With hydrogenchloride; In dichloromethane; water; ethyl acetate;

Reference yield:

: 1211473-15-2
(1S,3R)-3-[4-(benzyloxy)phenyl]-N-[(1R)-1-(naphthalen-1-yl)ethyl]cyclopentanamine

: 1211471-88-3
{4-[(1R,3S)-3-{[(1R)-1-(Naphthalen-1-yl)ethyl]amino}cyclopentyl]phenoxy}acetic acid hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen / palladium 10% on activated carbon / methanol / 16 h / 20 °C / Inert atmosphere

2: potassium carbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

3: sodium hydroxide; water / ethanol / 1 h / 20 °C

4: hydrogenchloride / dichloromethane; ethyl acetate; water

With hydrogenchloride; water; hydrogen; potassium carbonate; sodium hydroxide; palladium 10% on activated carbon; In methanol; ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1157579-86-6
{4-[(1R,3S)-3-{[(1R)-1-(Naphthalen-1-yl)ethyl]amino}cyclopentyl]phenoxy}acetic acid ethyl ester

: 1211471-88-3
{4-[(1R,3S)-3-{[(1R)-1-(Naphthalen-1-yl)ethyl]amino}cyclopentyl]phenoxy}acetic acid hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide; water / ethanol / 1 h / 20 °C

2: hydrogenchloride / dichloromethane; ethyl acetate; water

With hydrogenchloride; water; sodium hydroxide; In ethanol; dichloromethane; water; ethyl acetate;