[3,5-dichloro-4-(6-methoxy-4'-trifluoromethyl-biphenyl-3-yloxy)-phenyl]-acetic acid methyl ester

Base Information

Chemical Name:[3,5-dichloro-4-(6-methoxy-4'-trifluoromethyl-biphenyl-3-yloxy)-phenyl]-acetic acid methyl ester
CAS No.:788824-24-8
Molecular Formula:C₂₃H₁₇Cl₂F₃O₄
Molecular Weight:485.287
Hs Code.:

Synonyms:[3,5-dichloro-4-(6-methoxy-4'-trifluoromethyl-biphenyl-3-yloxy)-phenyl]-acetic acid methyl ester

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Chemical Property of [3,5-dichloro-4-(6-methoxy-4'-trifluoromethyl-biphenyl-3-yloxy)-phenyl]-acetic acid methyl ester

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Technology Process of [3,5-dichloro-4-(6-methoxy-4'-trifluoromethyl-biphenyl-3-yloxy)-phenyl]-acetic acid methyl ester

There total 8 articles about [3,5-dichloro-4-(6-methoxy-4'-trifluoromethyl-biphenyl-3-yloxy)-phenyl]-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 402-43-7
p-trifluoromethylphenyl bromide

: 788824-23-7
C₂₂H₂₅BCl₂O₆

: 788824-24-8
[3,5-dichloro-4-(6-methoxy-4'-trifluoromethyl-biphenyl-3-yloxy)-phenyl]-acetic acid methyl ester

Guidance literature:: With potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In dimethyl sulfoxide; at 80 ℃; for 1.5h; Inert atmosphere;

Reference yield:

: 402-43-7
p-trifluoromethylphenyl bromide

: {3,5-dichloro-4-[3-(4,5-dimethyl-[1,3,2]dioxaborolan-2-yl)-4-methoxy-phenoxy]-phenyl}-acetic acid methyl ester

: 788824-24-8
[3,5-dichloro-4-(6-methoxy-4'-trifluoromethyl-biphenyl-3-yloxy)-phenyl]-acetic acid methyl ester

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; water; at 80 ℃;
DOI:10.1016/j.bmcl.2004.04.032

Reference yield:

: 3336-41-2
3,5-dichloro-4-hydroxybenzoic acid

: 788824-24-8
[3,5-dichloro-4-(6-methoxy-4'-trifluoromethyl-biphenyl-3-yloxy)-phenyl]-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: oxalyl chloride; DMF / CH₂Cl₂

2: diethyl ether

3: PhCO₂Ag; Et₃N

4: Cu; Et₃N / CH₂Cl₂

5: Br₂ / CH₂Cl₂

6: PdCl₂dppf; KOAc / dimethylsulfoxide / 85 °C

7: Na₂CO₃; Pd(PPh₃)4 / 1,2-dimethoxy-ethane; H₂O / 80 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; oxalyl dichloride; bromine; potassium acetate; silver benzoate; copper; sodium carbonate; triethylamine; N,N-dimethyl-formamide; In 1,2-dimethoxyethane; diethyl ether; dichloromethane; water; dimethyl sulfoxide;
DOI:10.1016/j.bmcl.2004.04.032