methyl 1,2-dihydro-6,7-dimethoxy-1-phenylnaphthalene-3-carboxylate

Base Information

• Chemical Name: methyl 1,2-dihydro-6,7-dimethoxy-1-phenylnaphthalene-3-carboxylate
• CAS No.: 1225188-81-7
• Molecular Formula: C₂₀H₂₀O₄
• Molecular Weight: 324.376
• Mol file: 1225188-81-7.mol

Synonyms:methyl 1,2-dihydro-6,7-dimethoxy-1-phenylnaphthalene-3-carboxylate

Chemical Property of methyl 1,2-dihydro-6,7-dimethoxy-1-phenylnaphthalene-3-carboxylate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of methyl 1,2-dihydro-6,7-dimethoxy-1-phenylnaphthalene-3-carboxylate

There total 10 articles about methyl 1,2-dihydro-6,7-dimethoxy-1-phenylnaphthalene-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

methyl 1-((3,4-dimethoxyphenyl)(hydroxy)methyl)-2-phenylcyclopropane-1-carboxylate → methyl 1,2-dihydro-6,7-dimethoxy-1-phenylnaphthalene-3-carboxylate (1225188-81-7)

Guidance literature:

With scandium tris(trifluoromethanesulfonate); In 1,2-dichloro-ethane; at 83 ℃; for 1h; Inert atmosphere;

DOI:10.1246/cl.2010.194

Reference yield: 76.0%

methyl 1-((3,4-dimethoxyphenyl)(hydroxy)methyl)-2-phenylcyclopropane-1-carboxylate → methyl 1,2-dihydro-6,7-dimethoxy-1-phenylnaphthalene-3-carboxylate (1225188-81-7) + methyl 6,7-dimethoxy-4-phenyl-3,4-dihydronaphthalene-2-carboxylate

Guidance literature:

With calcium(II) bis(trifluoromethanesulfonyl)imide; tert-butylammonium hexafluorophosphate(V); In 1,2-dichloro-ethane; at 84 ℃; for 0.5h; Reagent/catalyst; Solvent; Temperature; regioselective reaction; Molecular sieve; Inert atmosphere;

DOI:10.1021/acs.orglett.6b01933

Reference yield: 74.0%

methyl 1-(acetoxy(3,4-dimethoxyphenyl)methyl)-2-phenylcyclopropane-1-carboxylate → methyl 1,2-dihydro-6,7-dimethoxy-1-phenylnaphthalene-3-carboxylate (1225188-81-7) + methyl 6,7-dimethoxy-4-phenyl-3,4-dihydronaphthalene-2-carboxylate

Guidance literature:

With calcium(II) bis(trifluoromethanesulfonyl)imide; tert-butylammonium hexafluorophosphate(V); In 1,2-dichloro-ethane; regioselective reaction; Molecular sieve; Inert atmosphere; Reflux;

DOI:10.1021/acs.orglett.6b01933

upstream raw materials:

benzaldehyde