Technology Process of N-[(2R,3S,4S,4aS,8aS)-4-[(3,5-dimethoxyphenyl)carbonyl]-3,4a,8,8-tetramethyldecahydronaphthalen-2-yl]-4-methylpiperazine-1-carboxamide
There total 10 articles about N-[(2R,3S,4S,4aS,8aS)-4-[(3,5-dimethoxyphenyl)carbonyl]-3,4a,8,8-tetramethyldecahydronaphthalen-2-yl]-4-methylpiperazine-1-carboxamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
1-Methylpyrrolidine;
In
toluene;
at 100 ℃;
for 25h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: pyridinium chlorochromate / dichloromethane / 2 h / 20 °C
2.1: tin(IV) chloride / dichloromethane / 0.17 h / 0 °C / Inert atmosphere
3.1: borane-THF / tetrahydrofuran / 1.67 h / 0 - 20 °C / Inert atmosphere
3.2: 1.33 h / 0 - 65 °C
4.1: pyridinium chlorochromate / dichloromethane / 4 h / 20 °C
5.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 22.5 h / 20 °C / Inert atmosphere
6.1: hydrogenchloride; palladium 10% on activated carbon; hydrogen / methanol; water / 23 h / 20 °C / 760.05 Torr
7.1: triethylamine / tetrahydrofuran / 23 h / 0 - 20 °C / Inert atmosphere
8.1: 1-Methylpyrrolidine / toluene / 25 h / 100 °C / Inert atmosphere
With
1-Methylpyrrolidine; hydrogenchloride; borane-THF; palladium 10% on activated carbon; hydrogen; tin(IV) chloride; sodium tris(acetoxy)borohydride; acetic acid; triethylamine; pyridinium chlorochromate;
In
tetrahydrofuran; methanol; dichloromethane; water; toluene;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: tin(IV) chloride / dichloromethane / 0.17 h / 0 °C / Inert atmosphere
2.1: borane-THF / tetrahydrofuran / 1.67 h / 0 - 20 °C / Inert atmosphere
2.2: 1.33 h / 0 - 65 °C
3.1: pyridinium chlorochromate / dichloromethane / 4 h / 20 °C
4.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 22.5 h / 20 °C / Inert atmosphere
5.1: hydrogenchloride; palladium 10% on activated carbon; hydrogen / methanol; water / 23 h / 20 °C / 760.05 Torr
6.1: triethylamine / tetrahydrofuran / 23 h / 0 - 20 °C / Inert atmosphere
7.1: 1-Methylpyrrolidine / toluene / 25 h / 100 °C / Inert atmosphere
With
1-Methylpyrrolidine; hydrogenchloride; borane-THF; palladium 10% on activated carbon; hydrogen; tin(IV) chloride; sodium tris(acetoxy)borohydride; acetic acid; triethylamine; pyridinium chlorochromate;
In
tetrahydrofuran; methanol; dichloromethane; water; toluene;
