3-(2-(3-fluoropyridin-2-ylamino)pyrimidin-5-yl)-N-(4-morpholino-trans-cyclohexyl)imidazo[1,2-b]pyridazin-6-amine

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Chemical Name:3-(2-(3-fluoropyridin-2-ylamino)pyrimidin-5-yl)-N-(4-morpholino-trans-cyclohexyl)imidazo[1,2-b]pyridazin-6-amine
CAS No.:1400873-39-3
Molecular Formula:C₂₅H₂₈FN₉O
Molecular Weight:489.555
Hs Code.:

Synonyms:3-(2-(3-fluoropyridin-2-ylamino)pyrimidin-5-yl)-N-(4-morpholino-trans-cyclohexyl)imidazo[1,2-b]pyridazin-6-amine

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Chemical Property of 3-(2-(3-fluoropyridin-2-ylamino)pyrimidin-5-yl)-N-(4-morpholino-trans-cyclohexyl)imidazo[1,2-b]pyridazin-6-amine

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Technology Process of 3-(2-(3-fluoropyridin-2-ylamino)pyrimidin-5-yl)-N-(4-morpholino-trans-cyclohexyl)imidazo[1,2-b]pyridazin-6-amine

There total 5 articles about 3-(2-(3-fluoropyridin-2-ylamino)pyrimidin-5-yl)-N-(4-morpholino-trans-cyclohexyl)imidazo[1,2-b]pyridazin-6-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 17282-04-1
2-chloro-3-fluoropyridine

: 3-(2-aminopyridin-5-yl)-N-(4-morpholino-trans-cyclohexyl)imidazo[1,2-b]pyridazin-6-amine

: 1400873-39-3
3-(2-(3-fluoropyridin-2-ylamino)pyrimidin-5-yl)-N-(4-morpholino-trans-cyclohexyl)imidazo[1,2-b]pyridazin-6-amine

Guidance literature:: With caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; at 130 ℃; for 6h; Inert atmosphere; sealed tube;

Reference yield:

: 2615-25-0
trans-1,4-cyclohexyldiamine

: 1400873-39-3
3-(2-(3-fluoropyridin-2-ylamino)pyrimidin-5-yl)-N-(4-morpholino-trans-cyclohexyl)imidazo[1,2-b]pyridazin-6-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: 30 h / 180 °C / microwave irradiation

2.1: potassium carbonate; potassium iodide / butan-1-ol / 0.25 h / 0 °C

2.2: 16 h / 100 °C

3.1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide; water / 1 h / 100 °C / Inert atmosphere

4.1: caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 6 h / 130 °C / Inert atmosphere; sealed tube

With sodium carbonate; potassium carbonate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; potassium iodide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; N,N-dimethyl-formamide; butan-1-ol;

Reference yield:

: 13526-66-4
3-bromo-6-chloro-imidazo[1,2-b]pyridazine

: 1400873-39-3
3-(2-(3-fluoropyridin-2-ylamino)pyrimidin-5-yl)-N-(4-morpholino-trans-cyclohexyl)imidazo[1,2-b]pyridazin-6-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: 30 h / 180 °C / microwave irradiation

2.1: potassium carbonate; potassium iodide / butan-1-ol / 0.25 h / 0 °C

2.2: 16 h / 100 °C

3.1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide; water / 1 h / 100 °C / Inert atmosphere

4.1: caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 6 h / 130 °C / Inert atmosphere; sealed tube

With sodium carbonate; potassium carbonate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; potassium iodide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; N,N-dimethyl-formamide; butan-1-ol;