5-Azido-2-benzyloxycarbonylamino-4,4-difluoro-pentanoic acid tert-butyl ester

Base Information

Chemical Name:5-Azido-2-benzyloxycarbonylamino-4,4-difluoro-pentanoic acid tert-butyl ester
CAS No.:175548-88-6
Molecular Formula:C₁₇H₂₂F₂N₄O₄
Molecular Weight:384.383
Hs Code.:

Synonyms:5-Azido-2-benzyloxycarbonylamino-4,4-difluoro-pentanoic acid tert-butyl ester

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Chemical Property of 5-Azido-2-benzyloxycarbonylamino-4,4-difluoro-pentanoic acid tert-butyl ester

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Technology Process of 5-Azido-2-benzyloxycarbonylamino-4,4-difluoro-pentanoic acid tert-butyl ester

There total 6 articles about 5-Azido-2-benzyloxycarbonylamino-4,4-difluoro-pentanoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 175548-87-5
2-Benzyloxycarbonylamino-4,4-difluoro-5-trifluoromethanesulfonyloxy-pentanoic acid tert-butyl ester

: 175548-88-6
5-Azido-2-benzyloxycarbonylamino-4,4-difluoro-pentanoic acid tert-butyl ester

Guidance literature:: With sodium azide; In N,N-dimethyl-formamide; at 40 ℃; for 1.5h;
DOI:10.1021/jo952044+

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 175548-88-6
5-Azido-2-benzyloxycarbonylamino-4,4-difluoro-pentanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 85 percent / NaHCO₃ / H₂O / 9 h / Ambient temperature

2: 89 percent / sulfuric acid / CH₂Cl₂ / 120 h / Ambient temperature

3: 81 percent / NaBH₄ / tetrahydrofuran; methanol / 12 h / Ambient temperature

4: 932 mg / diisopropylethylamine / CH₂Cl₂ / 0.75 h / Ambient temperature

5: 529 mg / NaN₃ / dimethylformamide / 1.5 h / 40 °C

With sodium tetrahydroborate; sodium azide; sulfuric acid; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jo952044+

Reference yield:

: 173282-21-8
DL-4,4-difluoroglutamic acid

: 175548-88-6
5-Azido-2-benzyloxycarbonylamino-4,4-difluoro-pentanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 85 percent / NaHCO₃ / H₂O / 9 h / Ambient temperature

2: 89 percent / sulfuric acid / CH₂Cl₂ / 120 h / Ambient temperature

3: 81 percent / NaBH₄ / tetrahydrofuran; methanol / 12 h / Ambient temperature

4: 932 mg / diisopropylethylamine / CH₂Cl₂ / 0.75 h / Ambient temperature

5: 529 mg / NaN₃ / dimethylformamide / 1.5 h / 40 °C

With sodium tetrahydroborate; sodium azide; sulfuric acid; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jo952044+