N-((S)-3-{2-ethyl-4-[5-(6-isobutyl-4-methylpyridin-2-yl)-[1,2,4]oxadiazol-3-yl]-6-methylphenoxy}-2-hydroxypropyl)-2-hydroxyacetamide

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Chemical Name:N-((S)-3-{2-ethyl-4-[5-(6-isobutyl-4-methylpyridin-2-yl)-[1,2,4]oxadiazol-3-yl]-6-methylphenoxy}-2-hydroxypropyl)-2-hydroxyacetamide
CAS No.:1186605-99-1
Molecular Formula:C₂₆H₃₄N₄O₅
Molecular Weight:482.58
Hs Code.:

Synonyms:N-((S)-3-{2-ethyl-4-[5-(6-isobutyl-4-methylpyridin-2-yl)-[1,2,4]oxadiazol-3-yl]-6-methylphenoxy}-2-hydroxypropyl)-2-hydroxyacetamide

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Chemical Property of N-((S)-3-{2-ethyl-4-[5-(6-isobutyl-4-methylpyridin-2-yl)-[1,2,4]oxadiazol-3-yl]-6-methylphenoxy}-2-hydroxypropyl)-2-hydroxyacetamide

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Technology Process of N-((S)-3-{2-ethyl-4-[5-(6-isobutyl-4-methylpyridin-2-yl)-[1,2,4]oxadiazol-3-yl]-6-methylphenoxy}-2-hydroxypropyl)-2-hydroxyacetamide

There total 12 articles about N-((S)-3-{2-ethyl-4-[5-(6-isobutyl-4-methylpyridin-2-yl)-[1,2,4]oxadiazol-3-yl]-6-methylphenoxy}-2-hydroxypropyl)-2-hydroxyacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

: 1122090-56-5
6-isobutyl-4-methylpyridine-2-carboxylic acid hydrochloride

: 1150644-70-4
N-((S)-3-[2-ethyl-4-(N-hydroxycarbamimidoyl)-6-methyl-phenoxy]-2-hydroxy-propyl)-2-hydroxy-acetamide

: 1186605-99-1
N-((S)-3-{2-ethyl-4-[5-(6-isobutyl-4-methylpyridin-2-yl)-[1,2,4]oxadiazol-3-yl]-6-methylphenoxy}-2-hydroxypropyl)-2-hydroxyacetamide

Guidance literature:: 6-isobutyl-4-methylpyridine-2-carboxylic acid hydrochloride; N-((S)-3-[2-ethyl-4-(N-hydroxycarbamimidoyl)-6-methyl-phenoxy]-2-hydroxy-propyl)-2-hydroxy-acetamide; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;

In 1,4-dioxane; at 100 ℃; Reagent/catalyst; Inert atmosphere;
DOI:10.1021/jm4014696

Reference yield:

: C₂₆H₃₆N₄O₆

: 1186605-99-1
N-((S)-3-{2-ethyl-4-[5-(6-isobutyl-4-methylpyridin-2-yl)-[1,2,4]oxadiazol-3-yl]-6-methylphenoxy}-2-hydroxypropyl)-2-hydroxyacetamide

Guidance literature:: In 1,4-dioxane; at 80 ℃; for 24h;

Reference yield:

: 1122090-52-1
4-methyl-6-(2-methylpropenyl)pyridine-2-carboxylic acid ethyl ester

: 1186605-99-1
N-((S)-3-{2-ethyl-4-[5-(6-isobutyl-4-methylpyridin-2-yl)-[1,2,4]oxadiazol-3-yl]-6-methylphenoxy}-2-hydroxypropyl)-2-hydroxyacetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; ethanol / 15 h / 50 °C / 750.08 Torr / Inert atmosphere

2.1: hydrogenchloride / water / 18 h / 65 °C

3.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

3.2: 100 °C / Inert atmosphere

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm4014696