(S)-4-[[2-[3-(4-Fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]ethyl]hydroxyphosphinyl]-3-hydroxy-butanoic acid, dilithium salt

Base Information

Chemical Name:(S)-4-[[2-[3-(4-Fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]ethyl]hydroxyphosphinyl]-3-hydroxy-butanoic acid, dilithium salt
CAS No.:119901-65-4
Molecular Formula:C₂₃H₂₅FNO₅P*2Li
Molecular Weight:459.309
Hs Code.:

Synonyms:(S)-4-[[2-[3-(4-Fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]ethyl]hydroxyphosphinyl]-3-hydroxy-butanoic acid, dilithium salt

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Chemical Property of (S)-4-[[2-[3-(4-Fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]ethyl]hydroxyphosphinyl]-3-hydroxy-butanoic acid, dilithium salt

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Technology Process of (S)-4-[[2-[3-(4-Fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]ethyl]hydroxyphosphinyl]-3-hydroxy-butanoic acid, dilithium salt

There total 3 articles about (S)-4-[[2-[3-(4-Fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]ethyl]hydroxyphosphinyl]-3-hydroxy-butanoic acid, dilithium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 119900-83-3
(S)-3-(tert-Butyl-diphenyl-silanyloxy)-4-{[3-(4-fluoro-phenyl)-1-isopropyl-1H-indol-2-ylethynyl]-methoxy-phosphinoyl}-butyric acid methyl ester

: 119901-65-4
(S)-4-[[2-[3-(4-Fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]ethyl]hydroxyphosphinyl]-3-hydroxy-butanoic acid, dilithium salt

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / Pd/C / methanol

2: n-Bu₄NF, AcOH / tetrahydrofuran

3: 1 N LiOH / dioxane

With lithium hydroxide; tetrabutyl ammonium fluoride; hydrogen; acetic acid; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol;
DOI:10.1021/jm00173a007

Reference yield:

: 119901-82-5
(S)-4-({2-[3-(4-Fluoro-phenyl)-1-isopropyl-1H-indol-2-yl]-ethyl}-methoxy-phosphinoyl)-3-hydroxy-butyric acid methyl ester

: 119901-65-4
(S)-4-[[2-[3-(4-Fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]ethyl]hydroxyphosphinyl]-3-hydroxy-butanoic acid, dilithium salt

Guidance literature:: With lithium hydroxide; In 1,4-dioxane;
DOI:10.1021/jm00173a007

Reference yield:

: 119900-84-4
(S)-3-(tert-Butyl-diphenyl-silanyloxy)-4-({2-[3-(4-fluoro-phenyl)-1-isopropyl-1H-indol-2-yl]-ethyl}-methoxy-phosphinoyl)-butyric acid methyl ester

: 119901-65-4
(S)-4-[[2-[3-(4-Fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]ethyl]hydroxyphosphinyl]-3-hydroxy-butanoic acid, dilithium salt

Guidance literature:: Multi-step reaction with 2 steps

1: n-Bu₄NF, AcOH / tetrahydrofuran

2: 1 N LiOH / dioxane

With lithium hydroxide; tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran; 1,4-dioxane;
DOI:10.1021/jm00173a007