{(3S)-1-[(1S,2R,4R)-4-tert-butoxycarbonylamino-2-propylcyclohexyl]-2-oxopyrrolidin-3-yl}carbamic acid benzyl ester

Base Information

Chemical Name:{(3S)-1-[(1S,2R,4R)-4-tert-butoxycarbonylamino-2-propylcyclohexyl]-2-oxopyrrolidin-3-yl}carbamic acid benzyl ester
CAS No.:848001-45-6
Molecular Formula:C₂₆H₃₉N₃O₅
Molecular Weight:473.613
Hs Code.:

Synonyms:{(3S)-1-[(1S,2R,4R)-4-tert-butoxycarbonylamino-2-propylcyclohexyl]-2-oxopyrrolidin-3-yl}carbamic acid benzyl ester

Suppliers and Price of {(3S)-1-[(1S,2R,4R)-4-tert-butoxycarbonylamino-2-propylcyclohexyl]-2-oxopyrrolidin-3-yl}carbamic acid benzyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of {(3S)-1-[(1S,2R,4R)-4-tert-butoxycarbonylamino-2-propylcyclohexyl]-2-oxopyrrolidin-3-yl}carbamic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of {(3S)-1-[(1S,2R,4R)-4-tert-butoxycarbonylamino-2-propylcyclohexyl]-2-oxopyrrolidin-3-yl}carbamic acid benzyl ester

There total 6 articles about {(3S)-1-[(1S,2R,4R)-4-tert-butoxycarbonylamino-2-propylcyclohexyl]-2-oxopyrrolidin-3-yl}carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 848001-44-5
C₂₈H₄₆N₃O₅S⁽¹⁺⁾*I^(1-)

: 848001-45-6
{(3S)-1-[(1S,2R,4R)-4-tert-butoxycarbonylamino-2-propylcyclohexyl]-2-oxopyrrolidin-3-yl}carbamic acid benzyl ester

Guidance literature:: With caesium carbonate; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 12h;

Reference yield:

: 746670-91-7
(1R,2S,5R)-tert-butyl 2-(benzyloxycarbonylamino)-7-oxo-6-azabicyclo[3.2.1]octane-6-carboxylate

: 848001-45-6
{(3S)-1-[(1S,2R,4R)-4-tert-butoxycarbonylamino-2-propylcyclohexyl]-2-oxopyrrolidin-3-yl}carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: diisobutylaluminium hydride / dichloromethane; tetrahydrofuran / 1.75 h / 0 °C

2: potassium hexamethylsilazane / tetrahydrofuran; toluene / 0.42 h / 0 °C

3: 5%-palladium/activated carbon; hydrogen / methanol / 4 h / 760.05 Torr

4: N-ethyl-N,N-diisopropylamine; BOP / dichloromethane; N,N-dimethyl-formamide / 12 h / 20 °C

5: ethyl acetate / 48 h / 20 °C

6: caesium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

With 5%-palladium/activated carbon; BOP; hydrogen; potassium hexamethylsilazane; diisobutylaluminium hydride; caesium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ml500505q

Reference yield:

: 847955-78-6
tert-butyl (1R,2S,5R,7R/S)-2-(benzyloxycarbonylamino)-7-hydroxy-6-aza-bicyclo[3.2.1]octane-6-carboxylate

: 848001-45-6
{(3S)-1-[(1S,2R,4R)-4-tert-butoxycarbonylamino-2-propylcyclohexyl]-2-oxopyrrolidin-3-yl}carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: potassium hexamethylsilazane / tetrahydrofuran; toluene / 0.42 h / 0 °C

2: 5%-palladium/activated carbon; hydrogen / methanol / 4 h / 760.05 Torr

3: N-ethyl-N,N-diisopropylamine; BOP / dichloromethane; N,N-dimethyl-formamide / 12 h / 20 °C

4: ethyl acetate / 48 h / 20 °C

5: caesium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

With 5%-palladium/activated carbon; BOP; hydrogen; potassium hexamethylsilazane; caesium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1021/ml500505q