Technology Process of (+)-(S)-3-(3,4-dichlorophenyl)-3-phenylpropan-1-ol
There total 4 articles about (+)-(S)-3-(3,4-dichlorophenyl)-3-phenylpropan-1-ol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(-)-(S)-1,2-dichloro-4-(1-phenylallyl)benzene;
With
9-borabicyclo[3.3.1]nonane;
In
tetrahydrofuran;
at 20 ℃;
Cooling with ice;
Inert atmosphere;
With
dihydrogen peroxide; sodium hydroxide;
In
tetrahydrofuran; ethanol; water;
at 20 ℃;
for 6h;
Inert atmosphere;
DOI:10.1002/anie.200904676
- Guidance literature:
-
1,2-dichloro-4-(1-phenylallyl)benzene;
With
borane-THF;
In
tetrahydrofuran;
at 0 - 20 ℃;
for 1.16667h;
Schlenk technique;
Inert atmosphere;
With
dihydrogen peroxide; sodium hydroxide;
In
water;
at 0 - 20 ℃;
for 1h;
Overall yield = 54 %; Overall yield = 31 mg;
DOI:10.1021/acs.orglett.5b03396
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: Inert atmosphere; Schlenk technique
1.2: Inert atmosphere; Schlenk technique
2.1: C45H42ClCuN2 / dichloromethane; dibutyl ether; hexane / -78 °C / Inert atmosphere; Schlenk technique
3.1: borane-THF / tetrahydrofuran / 1.17 h / 0 - 20 °C / Schlenk technique; Inert atmosphere
3.2: 1 h / 0 - 20 °C
With
borane-THF; C45H42ClCuN2;
In
tetrahydrofuran; hexane; dichloromethane; dibutyl ether;
DOI:10.1021/acs.orglett.5b03396
