3-(3-Cyclopentyloxy-4-methoxy-phenyl)-3-pyridin-4-ylmethyl-pyrrolidin-2-one

Base Information

Chemical Name:3-(3-Cyclopentyloxy-4-methoxy-phenyl)-3-pyridin-4-ylmethyl-pyrrolidin-2-one
CAS No.:203441-28-5
Molecular Formula:C₂₂H₂₆N₂O₃
Molecular Weight:366.46
Hs Code.:

Synonyms:3-(3-Cyclopentyloxy-4-methoxy-phenyl)-3-pyridin-4-ylmethyl-pyrrolidin-2-one

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Chemical Property of 3-(3-Cyclopentyloxy-4-methoxy-phenyl)-3-pyridin-4-ylmethyl-pyrrolidin-2-one

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Technology Process of 3-(3-Cyclopentyloxy-4-methoxy-phenyl)-3-pyridin-4-ylmethyl-pyrrolidin-2-one

There total 7 articles about 3-(3-Cyclopentyloxy-4-methoxy-phenyl)-3-pyridin-4-ylmethyl-pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 203440-78-2
3-(3-cyclopentyloxy-4-methoxy-phenyl)-2-oxo-3-pyridin-4-ylmethyl-pyrrolidine-1-carboxylic acid tert-butyl ester

: 203441-28-5
3-(3-Cyclopentyloxy-4-methoxy-phenyl)-3-pyridin-4-ylmethyl-pyrrolidin-2-one

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 2h; Ambient temperature;
DOI:10.1016/S0960-894X(98)00036-5

Reference yield:

: 1131-94-8
homoisovanillic acid

: 203441-28-5
3-(3-Cyclopentyloxy-4-methoxy-phenyl)-3-pyridin-4-ylmethyl-pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 7 steps

1: 95 percent / HCl (gas) / 20 h / Ambient temperature

2: 56 percent / K₂CO₃ / dimethylformamide / 20 h / 70 °C

3: 1.) KHMDS / 1.) dimethoxyethane, -78 deg C, 2.) dimethoxyethane, -78 deg C, 3 h

4: 57 percent / H₂ / Ra-Ni / methanol / 20 h / 50 °C

5: 63 percent / Et₃N, DMAP / 20 h / Ambient temperature

6: 48 percent / NaH / dimethylformamide / 20 h / Ambient temperature

7: 90 percent / TFA / CH₂Cl₂ / 2 h / Ambient temperature

With hydrogenchloride; dmap; hydrogen; potassium hexamethylsilazane; sodium hydride; potassium carbonate; triethylamine; trifluoroacetic acid; Ra-Ni; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(98)00036-5

Reference yield:

: 15964-81-5
methyl 3-hydroxy-4-methoxyphenylacetate

: 203441-28-5
3-(3-Cyclopentyloxy-4-methoxy-phenyl)-3-pyridin-4-ylmethyl-pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: 56 percent / K₂CO₃ / dimethylformamide / 20 h / 70 °C

2: 1.) KHMDS / 1.) dimethoxyethane, -78 deg C, 2.) dimethoxyethane, -78 deg C, 3 h

3: 57 percent / H₂ / Ra-Ni / methanol / 20 h / 50 °C

4: 63 percent / Et₃N, DMAP / 20 h / Ambient temperature

5: 48 percent / NaH / dimethylformamide / 20 h / Ambient temperature

6: 90 percent / TFA / CH₂Cl₂ / 2 h / Ambient temperature

With dmap; hydrogen; potassium hexamethylsilazane; sodium hydride; potassium carbonate; triethylamine; trifluoroacetic acid; Ra-Ni; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(98)00036-5