Azasetron hydrochloride

Base Information Edit

Chemical Name:Azasetron hydrochloride
CAS No.:123040-16-4
Deprecated CAS:132004-84-3,141922-90-9
Molecular Formula:C₁₇H₂₀ClN₃O₃*ClH
Molecular Weight:386.278
Hs Code.:
European Community (EC) Number:692-159-3
UNII:2BSS7XL60S
DSSTox Substance ID:DTXSID00924358
Wikipedia:Azasetron
Wikidata:Q27254532
NCI Thesaurus Code:C77260
ChEMBL ID:CHEMBL4303332
Mol file:123040-16-4.mol

Synonyms:azasetron;azasetron, (+-)-isomer;N-(1-azabicyclo(2.2.2)oct-3-yl)-6-chloro-4-methyl-3-oxo-3,4 -dihydro-2H-1,4-benzoxazine-8-carboxamide hydrochloride;Y 25130;Y-25130;WR 85915;WR-85915;WR85915

Suppliers and Price of Azasetron hydrochloride

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Y-25130 hydrochloride
10mg
$ 423.00

TRC
Azasetron hydrochloride
10mg
$ 110.00

Tocris
Y-25130hydrochloride ≥99%(HPLC)
50
$ 738.00

Tocris
Y-25130hydrochloride ≥99%(HPLC)
10
$ 180.00

Sigma-Aldrich
Azasetron hydrochloride ≥98% (HPLC)
5mg
$ 85.10

Sigma-Aldrich
Azasetron hydrochloride ≥98% (HPLC)
25mg
$ 344.00

Medical Isotopes, Inc.
AzasetronHCl
50 mg
$ 1880.00

Medical Isotopes, Inc.
AzasetronHCl
10 mg
$ 860.00

Matrix Scientific
Azasetron hydrochloride 95+%
1g
$ 2268.00

DC Chemicals
AzasetronHCL >99%
1 g
$ 800.00

Total 77 raw suppliers

Chemical Property of Azasetron hydrochloride Edit

Chemical Property:

Vapor Pressure:1.75E-12mmHg at 25°C
Melting Point:281° (dec); mp 305° (dec) (Kawakita)
Boiling Point:558 °C at 760 mmHg
Flash Point:291.2 °C
PSA：61.88000
LogP:2.71500
Storage Temp.:Desiccate at -20°C
Solubility.:Methanol (Slightly), Water (Slightly)
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:385.0959969
Heavy Atom Count:25
Complexity:523

Purity/Quality:

99% ^*data from raw suppliers

Y-25130 hydrochloride ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1C(=O)COC2=C(C=C(C=C21)Cl)C(=O)NC3CN4CCC3CC4.Cl
Description Nazasetron (azasetron) hydrochloride is the fourth in the class of highly potent 5- HT3 receptor antagonists to reach the market for prophylaxis of severe nausea and vomiting induced by cytotoxic chemotherapy and by total body X-radiation. In a study with 146 cancer patients suffering from emesis induced by cisplatin, nazasetron was reported to be markedly effective in 72% of subjects. Nazasetron is devoid of dopamine D2 receptor blocking activity and therefore is free of the extrapyrimidal side effects associated with other commonly used antiemetics such as metoclopramide and domperidone. Nazasetron has been reported to be potentially useful for the treatment of gastrointestinal motility dysfunction, such as gastric stasis, vomiting and irritable bowel syndrome.
Uses A 5-HT3 receptor antagonist. Used as an antiemetic. Azasetron HCl is a selective 5-HT3 receptor antagonist with IC50 of 0.33 nM used in the management of nausea and vomiting induced by cancer chemotherapy.
Therapeutic Function Antiemetic

Technology Process of Azasetron hydrochloride

There total 7 articles about Azasetron hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.3%