Chemical Property of Benazepril hydrochloride
Chemical Property:
- Appearance/Colour:crystalline solid
- Melting Point:188-190 °C
- Boiling Point:691.2 °C at 760 mmHg
- Flash Point:371.8 °C
- PSA：95.94000
- LogP:3.83100
- Storage Temp.:Desiccate at +4°C
- Solubility.:DMSO: ~34 mg/mL, soluble
- Hydrogen Bond Donor Count:3
- Hydrogen Bond Acceptor Count:6
- Rotatable Bond Count:10
- Exact Mass:460.1764997
- Heavy Atom Count:32
- Complexity:619
- Purity/Quality:
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99% HPLC *data from raw suppliers
Benazepril Hydrochloride *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- Safety Statements:
22-24/25
- MSDS Files:
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SDS file from LookChem
Total 1 MSDS from other Authors
Useful:
- Canonical SMILES:CCOC(=O)C(CCC1=CC=CC=C1)NC2CCC3=CC=CC=C3N(C2=O)CC(=O)O.Cl
- Isomeric SMILES:CCOC(=O)[C@H](CCC1=CC=CC=C1)N[C@H]2CCC3=CC=CC=C3N(C2=O)CC(=O)O.Cl
- Recent ClinicalTrials:Benazepril HCl 40 mg Tablets, Fed
- Recent EU Clinical Trials:A prospective, randomized, open label blinded end point probe trial to evaluate whether, at comparable blood pressure control, combined therapy with the ACE inhibitor Benazepril and the angiotensin II receptor blocker ARB Valsartan reduces progression to ESRD more effectively than Benazepril or Valsartan alone in high risk patients with type 2 diabetes and overt nephropathy VALID Study
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Description
Benazepril hydrochloride, a prodrug of benazeprilat, is a long-acting angiotensionconverting
enzyme (ACE) inhibitor useful in the treatment of essential hypertension.
In healthy humans, it was well tolerated and showed no phmacokinetic interactions
with furosemide, hydrochlorothiazide, chlorthalidone, digoxin, cimetidine,
atenolol, or naproxen. Benazepril hydrochloride is under investigation as a
cardiostirnulant. Benazepril is a prodrug of the angiotensin converting enzyme (ACE) inhibitor benazeprilat . It is metabolized to benazeprilat by hepatic esterases. Benazepril inhibits the in vitro enzymatic activity of partially purified ACE isolated from rabbit lung (IC50 = 2 nM). It decreases the triglyceride and total cholesterol levels in normotensive rats when administered at a dose of 30 mg/kg and decreases aortic atherosclerosis in cholesterol-fed rabbits when administered at a dose of 3 mg/kg per day. Benazepril (0.1-10 mg/kg per day) reduces blood pressure in spontaneously hypertensive rats. It also decreases proteinuria in cats with chronic kidney disease when administered at doses ranging from 0.5 to 1 mg/kg per day. Formulations containing benazepril have been used to treat hypertension, congestive heart failure, and chronic kidney disease in both human and veterinary medicine.
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Uses
Used as an antihypertensive; angiotensin converting enzyme inhibitor.
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Therapeutic Function
Antihypertensive
