(E)-9-(4-chlorobenzylidene)-3,5-bis(4-chlorophenyl)-6,7,8,9-tetrahydro-5H-pyrido[4,3-d]thiazolo[3,2-a]pyrimidine

Base Information

• Chemical Name: (E)-9-(4-chlorobenzylidene)-3,5-bis(4-chlorophenyl)-6,7,8,9-tetrahydro-5H-pyrido[4,3-d]thiazolo[3,2-a]pyrimidine
• CAS No.: 1547102-09-9
• Molecular Formula: C₂₈H₂₀Cl₃N₃S
• Molecular Weight: 536.912

Synonyms:(E)-9-(4-chlorobenzylidene)-3,5-bis(4-chlorophenyl)-6,7,8,9-tetrahydro-5H-pyrido[4,3-d]thiazolo[3,2-a]pyrimidine

Chemical Property of (E)-9-(4-chlorobenzylidene)-3,5-bis(4-chlorophenyl)-6,7,8,9-tetrahydro-5H-pyrido[4,3-d]thiazolo[3,2-a]pyrimidine

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Technology Process of (E)-9-(4-chlorobenzylidene)-3,5-bis(4-chlorophenyl)-6,7,8,9-tetrahydro-5H-pyrido[4,3-d]thiazolo[3,2-a]pyrimidine

There total 3 articles about (E)-9-(4-chlorobenzylidene)-3,5-bis(4-chlorophenyl)-6,7,8,9-tetrahydro-5H-pyrido[4,3-d]thiazolo[3,2-a]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

thiourea (17356-08-0) + 4-chlorobenzoylmethyl bromide (536-38-9) + (3E,5E)-3,5-bis(4-chlorobenzylidene)-4-piperidone (919091-60-4) → (E)-9-(4-chlorobenzylidene)-3,5-bis(4-chlorophenyl)-6,7,8,9-tetrahydro-5H-pyrido[4,3-d]thiazolo[3,2-a]pyrimidine (1547102-09-9)

Guidance literature:

thiourea; (3E,5E)-3,5-bis(4-chlorobenzylidene)-4-piperidone; for 0.25h; Ionic liquid; Microwave irradiation;

4-chlorobenzoylmethyl bromide; for 0.0333333h; Ionic liquid; Microwave irradiation;

DOI:10.1016/j.bmc.2013.11.020

Reference yield:

4-piperidone hydrochloride (41979-39-9) → (E)-9-(4-chlorobenzylidene)-3,5-bis(4-chlorophenyl)-6,7,8,9-tetrahydro-5H-pyrido[4,3-d]thiazolo[3,2-a]pyrimidine (1547102-09-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogenchloride; acetic acid

2.1: 0.25 h / Ionic liquid; Microwave irradiation

2.2: 0.03 h / Ionic liquid; Microwave irradiation

With hydrogenchloride; acetic acid; 1.1: |Claisen-Schmidt Condensation / 1.2: |Claisen-Schmidt Condensation;

DOI:10.1016/j.bmc.2013.11.020

Reference yield:

4-chlorobenzaldehyde (104-88-1) → (E)-9-(4-chlorobenzylidene)-3,5-bis(4-chlorophenyl)-6,7,8,9-tetrahydro-5H-pyrido[4,3-d]thiazolo[3,2-a]pyrimidine (1547102-09-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogenchloride; acetic acid

2.1: 0.25 h / Ionic liquid; Microwave irradiation

2.2: 0.03 h / Ionic liquid; Microwave irradiation

With hydrogenchloride; acetic acid; 1.1: |Claisen-Schmidt Condensation / 1.2: |Claisen-Schmidt Condensation;

DOI:10.1016/j.bmc.2013.11.020

upstream raw materials:

4-piperidone hydrochloride

4-chlorobenzaldehyde

thiourea

4-chlorobenzoylmethyl bromide

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