(R)-4-{(S)-2-[2-(2-tert-Butoxycarbonylamino-cyclohexyloxy)-acetylamino]-propionylamino}-4-carbamoyl-butyric acid benzyl ester

Base Information

Chemical Name:(R)-4-{(S)-2-[2-(2-tert-Butoxycarbonylamino-cyclohexyloxy)-acetylamino]-propionylamino}-4-carbamoyl-butyric acid benzyl ester
CAS No.:141949-72-6
Molecular Formula:C₂₈H₄₂N₄O₈
Molecular Weight:562.663
Hs Code.:

Synonyms:(R)-4-{(S)-2-[2-(2-tert-Butoxycarbonylamino-cyclohexyloxy)-acetylamino]-propionylamino}-4-carbamoyl-butyric acid benzyl ester

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Chemical Property of (R)-4-{(S)-2-[2-(2-tert-Butoxycarbonylamino-cyclohexyloxy)-acetylamino]-propionylamino}-4-carbamoyl-butyric acid benzyl ester

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Technology Process of (R)-4-{(S)-2-[2-(2-tert-Butoxycarbonylamino-cyclohexyloxy)-acetylamino]-propionylamino}-4-carbamoyl-butyric acid benzyl ester

There total 1 articles about (R)-4-{(S)-2-[2-(2-tert-Butoxycarbonylamino-cyclohexyloxy)-acetylamino]-propionylamino}-4-carbamoyl-butyric acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 59524-62-8
L-alanyl-D-isoglutamine benzyl ester hydrochloride

: 134962-04-2
trans-2-(2'-t-butyloxycarbonylaminocyclohexyloxy)acetic acid

: 141949-72-6
(R)-4-{(S)-2-[2-(2-tert-Butoxycarbonylamino-cyclohexyloxy)-acetylamino]-propionylamino}-4-carbamoyl-butyric acid benzyl ester

Guidance literature:: With diphenyl phosphoryl azide; triethylamine; In N,N-dimethyl-formamide; a) from 0 deg C to 2 deg C, 1 h, b) RT, 60 h;
DOI:10.1021/jm970509d

Reference yield: 90.0%

: 141949-72-6
(R)-4-{(S)-2-[2-(2-tert-Butoxycarbonylamino-cyclohexyloxy)-acetylamino]-propionylamino}-4-carbamoyl-butyric acid benzyl ester

: (R)-4-{(S)-2-[2-(2-Amino-cyclohexyloxy)-acetylamino]-propionylamino}-4-carbamoyl-butyric acid benzyl ester; hydrochloride

Guidance literature:: With hydrogenchloride; acetic acid;
DOI:10.1021/jm970509d

Reference yield:

: 141949-72-6
(R)-4-{(S)-2-[2-(2-tert-Butoxycarbonylamino-cyclohexyloxy)-acetylamino]-propionylamino}-4-carbamoyl-butyric acid benzyl ester

: (R)-4-Carbamoyl-4-{(S)-2-[2-(2-dodecanoylamino-cyclohexyloxy)-acetylamino]-propionylamino}-butyric acid

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / HCl(g), glacial AcOH

2: 70 percent / diphenyl phosphorazidate, Et₃N / dimethylformamide / a) from 0 deg C to 2 deg C, 1 h, b) RT, 60 h

3: 96 percent / H₂ / 10percent Pd/C / tetrahydrofuran / 1 h / Ambient temperature

With hydrogenchloride; diphenyl phosphoryl azide; hydrogen; acetic acid; triethylamine; palladium on activated charcoal; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm970509d