2-[3-{3-[4-(4-tert-butylbenzyl)piperazin-1-yl]-3-oxopropyl}-5-(4-methylphenyl)-1H-pyrazol-1-yl]quinoline

Base Information

Chemical Name:2-[3-{3-[4-(4-tert-butylbenzyl)piperazin-1-yl]-3-oxopropyl}-5-(4-methylphenyl)-1H-pyrazol-1-yl]quinoline
CAS No.:1339035-91-4
Molecular Formula:C₃₇H₄₁N₅O
Molecular Weight:571.765
Hs Code.:

Synonyms:2-[3-{3-[4-(4-tert-butylbenzyl)piperazin-1-yl]-3-oxopropyl}-5-(4-methylphenyl)-1H-pyrazol-1-yl]quinoline

Suppliers and Price of 2-[3-{3-[4-(4-tert-butylbenzyl)piperazin-1-yl]-3-oxopropyl}-5-(4-methylphenyl)-1H-pyrazol-1-yl]quinoline

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of 2-[3-{3-[4-(4-tert-butylbenzyl)piperazin-1-yl]-3-oxopropyl}-5-(4-methylphenyl)-1H-pyrazol-1-yl]quinoline

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2-[3-{3-[4-(4-tert-butylbenzyl)piperazin-1-yl]-3-oxopropyl}-5-(4-methylphenyl)-1H-pyrazol-1-yl]quinoline

There total 5 articles about 2-[3-{3-[4-(4-tert-butylbenzyl)piperazin-1-yl]-3-oxopropyl}-5-(4-methylphenyl)-1H-pyrazol-1-yl]quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.7%

: 956-61-6
1-(4-tert-butylbenzyl)piperazine

: 1339036-27-9
3-[5-(4-methylphenyl)-1-quinolin-2-yl-1H-pyrazol-3-yl]propanoic acid

: 1339035-91-4
2-[3-{3-[4-(4-tert-butylbenzyl)piperazin-1-yl]-3-oxopropyl}-5-(4-methylphenyl)-1H-pyrazol-1-yl]quinoline

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃;
DOI:10.1016/j.ejmech.2011.08.009

Reference yield:

: 15793-77-8
2-hydrazinoquinoline

: 1339035-91-4
2-[3-{3-[4-(4-tert-butylbenzyl)piperazin-1-yl]-3-oxopropyl}-5-(4-methylphenyl)-1H-pyrazol-1-yl]quinoline

Guidance literature:: Multi-step reaction with 2 steps

1: methanol / 4 h / Reflux

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; dichloromethane;
DOI:10.1016/j.ejmech.2011.08.009

Reference yield:

: 612-62-4
2-Chloroquinoline

: 1339035-91-4
2-[3-{3-[4-(4-tert-butylbenzyl)piperazin-1-yl]-3-oxopropyl}-5-(4-methylphenyl)-1H-pyrazol-1-yl]quinoline

Guidance literature:: Multi-step reaction with 3 steps

1: hydrazine hydrate

2: methanol / 4 h / Reflux

3: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C

With dmap; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; dichloromethane;
DOI:10.1016/j.ejmech.2011.08.009