1,5,5-triphenyl-3,3-dimethyl-4-(p-methoxyphenyl)-1-pentanone

Base Information

• Chemical Name: 1,5,5-triphenyl-3,3-dimethyl-4-(p-methoxyphenyl)-1-pentanone
• CAS No.: 104394-41-4
• Molecular Formula: C₃₂H₃₂O₂
• Molecular Weight: 448.605
• Mol file: 104394-41-4.mol

Synonyms:1,5,5-triphenyl-3,3-dimethyl-4-(p-methoxyphenyl)-1-pentanone

Chemical Property of 1,5,5-triphenyl-3,3-dimethyl-4-(p-methoxyphenyl)-1-pentanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,5,5-triphenyl-3,3-dimethyl-4-(p-methoxyphenyl)-1-pentanone

There total 10 articles about 1,5,5-triphenyl-3,3-dimethyl-4-(p-methoxyphenyl)-1-pentanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

(E)-1-methoxy-1,5,5-triphenyl-3,3-dimethyl-4-(p-methoxyphenyl)-1-pentene (104394-45-8) → 1,5,5-triphenyl-3,3-dimethyl-4-(p-methoxyphenyl)-1-pentanone (104394-41-4)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; for 15h; Ambient temperature;

DOI:10.1021/jo00374a022

Reference yield: 58.0%

(Z)-1-methoxy-1,5,5-triphenyl-3,3-dimethyl-4-(p-methoxyphenyl)-1-pentene (104394-43-6) → 1,5,5-triphenyl-3,3-dimethyl-4-(p-methoxyphenyl)-1-pentanone (104394-41-4)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; for 4h;

DOI:10.1021/jo00374a022

Reference yield:

2,2-diphenyl-2-(p-methoxyphenyl)ethanol (104394-32-3) → 1,5,5-triphenyl-3,3-dimethyl-4-(p-methoxyphenyl)-1-pentanone (104394-41-4)

Guidance literature:

Multi-step reaction with 8 steps

1: 87 percent / pyridinium chlorochromate / CH₂Cl₂ / 2 h

2: 59 percent / zinc / benzene / 36 h / Heating

3: 97 percent / ammonia, lithium / tetrahydrofuran / 2 h / Heating

4: 81 percent / lithium aluminum hydride / tetrahydrofuran / 10 h / Heating

5: 87 percent / pyridinium chlorochromate / CH₂Cl₂ / 1.5 h

6: 1.) potassium tert-butoxide / 1.) THF, 0 deg C, 2.0 h, 2.) THF, RT, 5.0 h

7: 71 percent / Jones reagent / acetone / 2 h

8: 1.) n-butyllithium / 1.) ether, hexane, 0 deg C, 1.0 h, 2.) ether, hexane, RT, 5.0 h

With lithium aluminium tetrahydride; n-butyllithium; jones reagent; potassium tert-butylate; ammonia; lithium; pyridinium chlorochromate; zinc; In tetrahydrofuran; dichloromethane; acetone; benzene;

DOI:10.1021/jo00374a022

upstream raw materials:

(E)-1-methoxy-1,5,5-triphenyl-3,3-dimethyl-4-(p-methoxyphenyl)-1-pentene

(Z)-1-methoxy-1,5,5-triphenyl-3,3-dimethyl-4-(p-methoxyphenyl)-1-pentene

2,2-diphenyl-2-(p-methoxyphenyl)ethanol

2,2-diphenyl-2-(p-methoxyphenyl)acetaldehyde