N-tert-Butyldecahydro-2-(2(R)-hydroxy-4-phenyl-3(S)phthalimidobutyl)-(4aS,8aS)-isoquinoline-3(S)-carboxamide

Base Information

Chemical Name:N-tert-Butyldecahydro-2-(2(R)-hydroxy-4-phenyl-3(S)phthalimidobutyl)-(4aS,8aS)-isoquinoline-3(S)-carboxamide
CAS No.:136465-78-6
Molecular Formula:C₃₂H₄₁N₃O₄
Molecular Weight:531.695
Hs Code.:

Synonyms:N-tert-Butyldecahydro-2-(2(R)-hydroxy-4-phenyl-3(S)phthalimidobutyl)-(4aS,8aS)-isoquinoline-3(S)-carboxamide

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Chemical Property of N-tert-Butyldecahydro-2-(2(R)-hydroxy-4-phenyl-3(S)phthalimidobutyl)-(4aS,8aS)-isoquinoline-3(S)-carboxamide

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Technology Process of N-tert-Butyldecahydro-2-(2(R)-hydroxy-4-phenyl-3(S)phthalimidobutyl)-(4aS,8aS)-isoquinoline-3(S)-carboxamide

There total 18 articles about N-tert-Butyldecahydro-2-(2(R)-hydroxy-4-phenyl-3(S)phthalimidobutyl)-(4aS,8aS)-isoquinoline-3(S)-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 128019-40-9,149510-73-6,136465-81-1,168899-60-3
(3S,4aS,8aS)-N-tert-butyl-decahydroisoquinoline-3-carboxamide

: 136465-80-0
2(S)-[2-phenyl-1(S)-phthalimidoethyl]oxirane

: 136465-78-6
N-tert-Butyldecahydro-2-(2(R)-hydroxy-4-phenyl-3(S)phthalimidobutyl)-(4aS,8aS)-isoquinoline-3(S)-carboxamide

Guidance literature:: In N,N-dimethyl-formamide; at 120 ℃; for 8.5h;
DOI:10.1021/jo00092a026

Reference yield:

: 63-91-2,25191-15-5,658-69-5,67675-33-6
L-phenylalanine

: 136465-78-6
N-tert-Butyldecahydro-2-(2(R)-hydroxy-4-phenyl-3(S)phthalimidobutyl)-(4aS,8aS)-isoquinoline-3(S)-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: 70 percent / aq. HCl

2: COCl₂

4: 85 percent / H₂ / Rh/Alox / ethyl acetate / 150 °C / 112509 Torr

5: dimethylformamide / 120 °C

With hydrogenchloride; hydrogen; Rh/Al₂O₃; In ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 74163-81-8
L-Tic-OH

: 136465-78-6
N-tert-Butyldecahydro-2-(2(R)-hydroxy-4-phenyl-3(S)phthalimidobutyl)-(4aS,8aS)-isoquinoline-3(S)-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: COCl₂

3: 85 percent / H₂ / Rh/Alox / ethyl acetate / 150 °C / 112509 Torr

4: dimethylformamide / 120 °C

With hydrogen; Rh/Al₂O₃; In ethyl acetate; N,N-dimethyl-formamide;